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Non-autonomous consequences of cell death and other perks of being metazoan

机译:细胞死亡和后生动物的其他非自治后果

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Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use of Drosophila to study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology.
机译:果蝇(Drosophila melanogaster)仍然是研究多细胞发育背景下基本细胞生物学过程的最重要的遗传模型。在这种情况下,一个单元格的行为会影响另一个单元格。细胞之间的非自主性信号传导贯穿后生动物的发展和疾病,而且范围太广,无法通过一次综述来涵盖。在这里,我将重点讨论响应幼虫上皮细胞死亡而发生的非自治信号事件,这些事件会影响存活细胞的生死决定。我将总结果蝇在研究细胞死亡诱导的增殖,凋亡诱导的凋亡和凋亡诱导的生存信号中的用途。果蝇的关键见解将在哺乳动物发育和癌症生物学的类似过程中进行讨论。

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