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Drosophila models of metastasis

机译：果蝇转移模型

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An important goal in the fight against cancer is to understand how tumors become invasive and metastatic. A crucial early step in metastasis is thought to be the epithelial mesenchymal transition (EMT), the process in which epithelial cells transition into a more migratory and invasive, mesenchymal state. Since the genetic regulatory networks driving EMT in tumors derive from those used in development, analysis of EMTs in genetic model organisms such as the vinegar fly, Drosophila melanogaster , can provide great insight into cancer. In this review I highlight the many ways in which studies in the fly are shedding light on cancer metastasis. The review covers both normal developmental events in which epithelial cells become migratory, as well as induced events, whereby normal epithelial cells become metastatic due to genetic manipulations. The ability to make such precise genetic perturbations in the context of a normal, in vivo environment, complete with a working innate immune system, is making the fly increasingly important in understanding metastasis.
机译：对抗癌症的一个重要目标是了解肿瘤如何变成浸润性和转移性。转移中至关重要的早期步骤被认为是上皮间质转化（EMT），在该过程中，上皮细胞转化为更具迁移性和侵入性的间质状态。由于在肿瘤中驱动EMT的遗传调控网络源自开发过程中使用的遗传调控网络，因此对遗传模型生物（如醋蝇，果蝇Drosophila melanogaster）中的EMT进行分析可以为癌症提供重要的见识。在这篇评论中，我强调了进行中的研究在许多方面揭示了癌症转移的方法。该综述涵盖了上皮细胞迁移的正常发育事件以及诱导事件，其中由于基因操作，正常上皮细胞成为转移性事件。在正常的体内环境中，结合正常的先天免疫系统，进行如此精确的遗传扰动的能力，使果蝇在了解转移方面变得越来越重要。

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