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Vitamin D receptor gene polymorphisms in Sudanese children with type 1 diabetes

机译：苏丹1型糖尿病儿童维生素D受体基因多态性

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Type 1 diabetes mellitus (T1DM) is a T cell mediated autoimmune disease. Vitamin D was found to suppress the incidence of diabetes when bind to its receptor (VDR), probably by suppressing T cell activations. Thus the VDR gene polymorphism may have an impact on pathophysiology of this disease. Since there was no consistent association between VDR polymorphisms and the risk of T1DM, this study aimed to investigate a VDR gene polymorphism in Sudanese children with T1DM. We examined the VDR gene Bsm 1 (rs1544410), Apa 1 (rs7975232), and Taq 1 (rs731236) single nucleotide polymorphisms in 174 children with T1DM, and 56 children as control, and the association of these polymorphisms with the diabetic control. Among study patients, the majority (85.63%) of diabetic patients reported metabolically poor controlled (HbA1c?>?8%). As compared with the control, patients with T1DM presented more commonly with Bsm 1 B allele ( p = 0.001; OR 0.283; 95% CI 0.131–0.609) and Taq 1 T allele ( p = 0.05; OR 2.429; 95% CI 1.073–5.496). Apa 1 A allele was less common in patients with T1DM without statistical difference ( p = 0.862; OR 1.085; 95% CI 0.546–2.156). Our study suggests that, Bsm 1 and Taq 1 polymorphisms of the VDR gene associated with the prevalence of T1DM.
机译：1型糖尿病（T1DM）是T细胞介导的自身免疫性疾病。发现维生素D与其受体（VDR）结合时可以抑制糖尿病的发生，这可能是通过抑制T细胞活化来实现的。因此，VDR基因多态性可能对该疾病的病理生理有影响。由于VDR多态性与T1DM风险之间没有一致的关联，因此本研究旨在调查苏丹T1DM儿童的VDR基因多态性。我们检查了174例T1DM儿童和56例儿童的VDR基因Bsm 1（rs1544410），Apa 1（rs7975232）和Taq 1（rs731236）单核苷酸多态性，并将这些多态性与糖尿病对照相关联。在研究患者中，大多数（85.63％）糖尿病患者报告其代谢控制不佳（HbA1c≥8％）。与对照组相比，T1DM患者更常见Bsm 1 B等位基因（p = 0.001; OR 0.283; 95％CI 0.131–0.609）和Taq 1 T等位基因（p = 0.05; OR 2.429; 95％CI 1.073– 5.496）。 A1等位基因在T1DM患者中较少见，无统计学差异（p = 0.862; OR 1.085; 95％CI 0.546–2.156）。我们的研究表明，VDR基因的Bsm 1和Taq 1多态性与T1DM的流行有关。

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