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A search for the common ground between Tic; Obsessive-compulsive and Autism Spectrum Disorders: part I, Tic disorders

机译：寻找Tic之间的共同点;强迫症和自闭症谱系障碍：第一部分，抽动症

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This article is the first of four articles designed to explore the complex interrelationship between Autism Spectrum Disorders (ASD); Obsessive compulsive and Related Disorders (OCRD) and Tic Disorders/Tourette’s Syndrome (TD/TS). We begin with an overview TD/TS and follow-up with reviews of OCRD and ASD. The final article in this series represents a synthesis of the neurobiological and genetic markers shared by patients presenting with all three syndromes. The goal is to describe the complex endophenotype of these patients in an effort to better define gene markers that underlie these heterogeneous clinical syndromes. Tic disorders (TD) are a collection of hyperkinetic movements that begin in early childhood. Tics are transient for most affected preschool children but a subgroup development persistent movements or progress to develop Tourette Syndrome (TS). TDs as a group display high heritability rates but definitive gene markers still elude us. The difficulty defining genetic markers is in large part due to the diverse neurodevelopmental trajectory, changing topography and typology, development of a broad spectrum of neurocognitive and behavioral complications, and a mixed pattern of psychiatric comorbidities.
机译：本文是旨在探讨自闭症谱系障碍（ASD）之间复杂的相互关系的四篇文章的第一篇;强迫症和相关疾病（OCRD）和抽动症/图雷特综合症（TD / TS）。我们首先从TD / TS概述开始，然后跟进对OCRD和ASD的审查。本系列的最后一篇文章介绍了所有三种综合症患者共享的神经生物学和遗传标记。目的是描述这些患者的复杂内表型，以更好地定义这些异质性临床综合征的基础基因标记。抽动症（TD）是从儿童早期开始的运动过度运动的集合。对于大多数受影响的学龄前儿童来说，抽动是短暂的，但是一个亚组发展为持续性运动或发展为抽动秽语综合症（TS）。 TDs作为一个整体显示出较高的遗传率，但确定的基因标记仍使我们望而却步。定义遗传标记的困难很大程度上归因于神经发育轨迹的多样性，地形和类型的变化，神经认知和行为并发症的广泛发展以及精神病合并症的混合模式。

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