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首页> 外文期刊>American journal of applied sciences >Inhibitory Effect of Ginger Extract on Candida albicans | Science Publications
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Inhibitory Effect of Ginger Extract on Candida albicans | Science Publications

机译：生姜提取物对白色念珠菌的抑制作用科学出版物

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> Problem statement:The fungal infections could be life-threatening in immunocompromised patients. Candida albicans is the most frequent fungi in the oral cavity. Approach: The first step for treatment could be done using topical antifungal agents. Nystatine is a choice for mentioned usage but there are some problems in its using including: unfavorite taste, frequency of usage, etc. Finding better replacements is the subject of many studies. Results: This study was carried out to find an alternative for Nystatine. The study was designed based on laboratory investigations to investigate the antifungal activity of zingiber offcinale (Ginger) on Candida albicans. Candida albicanse (PTCC 5027, ATCC10231) was obtained from Iranian microbial collection and was confirmed by Germ Tube formation test. Ethanolic ginger extract was prepared. The antifungal activity of the extract was determined using Agar dilution and disc diffusion techniques. Data were analyzed by ANOVA test. Conclusion/Recommendations:The results showed that the ethanolic extract was effective on Candida albicans (2 mg mL-1) at the concentration of 1:5. The study indicates that ginger extract might have promise in treatment of oral candidiasis.
机译： > 问题陈述：在免疫功能低下的患者中，真菌感染可能危及生命。白色念珠菌是口腔中最常见的真菌。 方法：第一步治疗可以使用局部抗真菌药。制霉菌素是上述用途的一种选择，但其使用中存在一些问题，包括：不良的口味，使用频率等。寻找更好的替代品是许多研究的主题。 结果：进行这项研究是为了寻找制霉菌素的替代品。该研究是在实验室调查的基础上设计的，旨在研究姜黄对白念珠菌的抗真菌活性。白念珠菌Candida albicanse（PTCC 5027，ATCC10231）是从伊朗微生物收集物中获得的，并通过毒菌管形成试验加以证实。制备了乙醇酚姜提取物。使用琼脂稀释和圆盘扩散技术确定提取物的抗真菌活性。通过ANOVA检验分析数据。 结论/建议：结果表明，乙醇提取物对白色念珠菌（2 mg mL -1 ）的浓度有效。研究表明，姜提取物可能在口腔念珠菌病的治疗中有希望。

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