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首页> 外文期刊>American journal of applied sciences >Vitamin E Mitigates Chronic Chlorpyrifos-Induced Oxidative Changes in Pituitary Glands and Testes in Wistar Rats | Science Publications
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Vitamin E Mitigates Chronic Chlorpyrifos-Induced Oxidative Changes in Pituitary Glands and Testes in Wistar Rats | Science Publications

机译：维生素E减轻了毒死P对Wistar大鼠垂体和睾丸的慢性氧化作用科学出版物

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> Problem statement: The sperm counts of men have declined by about 50% in the last few decades. The contribution of environmental contaminants to this decline cannot be overemphasized. Pesticide is one of the most pervasive environmental chemical contaminants that have been of increased use due to the compelling need to feed the ever-growing world human and animal population and protect their health. Chlorpyrifos (CPF), a widely used Organophosphate (OP) insecticide has been reported to alter male reproductive hormones and semen characteristics. Apart from acetyl cholinesterase inhibition, the induction of oxidative stress is one of the molecular mechanisms implicated in CPF poisoning. Approach: The present study was aimed at evaluating the effect of vitamin E in mitigating oxidative damage to the pituitary gland and the testis, induced by chronic CPF administration in Wistar rats. Methodology: Twenty adult male Wistar rats divided into 4 groups of 5 rats in each group were used for this study. Group I received soya oil (2 mL kg-1), while Group II was administered vitamin E (75 mg kg-1); Group III was administered CPF only (10.6 mg kg-1~1/8th LD50), while group IV was pretreated with vitamin E (75 mg kg-1) and exposed to CPF (10.6 mg kg-1) 30 min later. The regimens were administered orally by gavages once daily for a period of 15 weeks. At the end of the treatment period, the rats were sacrificed and the pituitary glands and testicular tissues were assayed for the concentrations of Malonaldehyde (MDA) and the activities of Superoxide Dismutase (SOD) and Catalane (CAT). Results: The result showed that the increase in concentrations of pituitary and testicular MDA and a decrease in the activities of SOD and CAT recorded in the group exposed to CPF were ameliorated by pretreatment with vitamin E. Conclusion: This indicates that vitamin E mitigates reproductive toxicity induced by chronic CPF exposure due to its protective antioxidant activity on pituitary glands and the testes.
机译： > 问题陈述：在过去的几十年中，男性的精子数量下降了约50％。不能过分强调环境污染物对这一下降的贡献。农药是最普遍的环境化学污染物之一，由于迫切需要养活不断增长的世界人类和动物种群并保护其健康，因此已被广泛使用。毒死rif（CPF）是一种广泛使用的有机磷（OP）杀虫剂，可改变男性生殖激素和精液的特性。除了抑制乙酰胆碱酯酶外，氧化应激的诱导也是与CPF中毒有关的分子机制之一。 方法：本研究旨在评估维生素E在减轻Wistar大鼠长期CPF引起的对垂体和睾丸的氧化损伤中的作用。方法：将20只成年雄性Wistar大鼠分为4组，每组5只。第一组服用大豆油（2 mL kg -1 ），第二组服用维生素E（75 mg kg -1 ）;第三组仅接受CPF（10.6 mg kg -1 〜1/8 LD 50 ），而第四组仅接受维生素E（75 mg kg - 1 ）并在30分钟后暴露于CPF（10.6 mg kg -1 ）。每天一次通过管饲法口服该方案，持续15周。在治疗期结束时，处死大鼠并测定垂体和睾丸组织的丙二醛（MDA）浓度以及超氧化物歧化酶（SOD）和过氧化氢（CAT）的活性。 结果：结果表明，维生素E预处理可减轻CPF组中垂体和睾丸MDA的浓度增加以及SOD和CAT活性的降低。结论：这表明维生素E可以减轻慢性CPF暴露引起的生殖毒性，因为它对垂体和睾丸具有保护性抗氧化活性。

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