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首页> 外文期刊>Alzheimer s Research & Therapy >Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?
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Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?

机译:现在是基于生物标志物的前驱性阿尔茨海默氏病诊断标准的时候了吗?

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Drug candidates targeting amyloid-β (Aβ) pathology in Alzheimer's disease are in different phases of clinical trials. These treatments will probably be most effective in the earlier stages of the disease, before neurodegeneration is too severe, but at the same time symptoms are vague and the clinical diagnosis is difficult. Recent research advances have resulted in promising biomarkers, including cerebrospinal fluid analyses for tau and Aβ, magnetic resonance imaging measurement of atrophy, and positron emission tomography imaging of glucose metabolism and Aβ pathology, which allow identification of prodromal Alzheimer's disease. More details are needed, however, on how these biomarkers can be standardized, to allow a general implementation in the clinical routine diagnostic work-up of patients with cognitive disturbances.
机译:针对阿尔茨海默氏病中的淀粉样β(Aβ)病理学的候选药物处于临床试验的不同阶段。在神经变性太严重之前,这些治疗可能在疾病的早期阶段是最有效的,但同时症状模糊且临床诊断困难。最近的研究进展已经产生了令人鼓舞的生物标志物,包括脑脊液中tau和Aβ的分析,磁共振成像对萎缩的成像测量以及葡萄糖代谢和Aβ病理的正电子发射断层扫描成像,从而可以识别前驱性阿尔茨海默氏病。然而,需要更多关于如何标准化这些生物标记物的细节,以允许在认知障碍患者的临床常规诊断检查中普遍实施。

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