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首页> 外文期刊>American journal of applied sciences >POTENTIAL CANCER CHEMOPREVENTIVE ACTIVITY OF STYRYLLACTONES FROM GONIOTHALAMUS MARCANII | Science Publications
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POTENTIAL CANCER CHEMOPREVENTIVE ACTIVITY OF STYRYLLACTONES FROM GONIOTHALAMUS MARCANII | Science Publications

机译：马鞭鱼角型内酯的潜在癌化学活性科学出版物

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> Goniothalamus plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. Members of this family are rich in a wide variety of biological active compounds including alkaloids, acetogenins and styryllactones. The present research described phytochemical study of the leaves and twigs of G. marcanii together with their cytotoxicity. The G. marcanii was selected and percolated with hexane, ethyl acetate and methanol. The extracts were purified and elucidated chemical structures. The constituents of ethyl acetate extract of G. marcanii have been investigated. We isolated and identified three derivative styryllactones e.g., 5-hydroxygoniothalamin (1), 5-acetylgoniothalamin (2) and goniopypyrone (3). The structures of these compounds were elucidated on the basis of spectroscopic evidence. Studies on ethyl acetate extract of G. marcanii have now resulted the isolation and structural characterization of three styryllactones. Their anticancer activities were evaluated using SRB assays. In this method, compound 1 and 2 showed potential activity in cell lines.
机译： > 角鲨科植物属于番荔枝科，在泰国发现，并已被用作泰国的传统药物。该家族的成员富含多种生物活性化合物，包括生物碱，产乙酸素和苯乙烯基内酯。本研究描述了 G的叶子和细枝的植物化学研究。 marcanii 及其细胞毒性。 G。选择marcanii并用己烷，乙酸乙酯和甲醇渗透。提取物经过纯化并阐明了化学结构。 G的乙酸乙酯提取物的成分。 marcanii 已被调查。我们分离并鉴定了三种衍生的苯乙烯基内酯，例如5-羟基gonthiothalamin（1），5-acetylgoniothalamin（2）和goniopypyrone（3）。根据光谱证据阐明了这些化合物的结构。 G的乙酸乙酯提取物的研究。现在，marcanii 导致了三种苯乙烯基内酯的分离和结构表征。使用SRB分析评估其抗癌活性。在这种方法中，化合物1和2在细胞系中显示出潜在的活性。

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