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首页> 外文期刊>American journal of applied sciences >ANTICANCER ACTIVITY OF ISOLATED CHEMICAL CONSTITUENTS FROM MILIUSA SMITHIAE | Science Publications
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ANTICANCER ACTIVITY OF ISOLATED CHEMICAL CONSTITUENTS FROM MILIUSA SMITHIAE | Science Publications

机译：粟米中分离出的化学成分的抗癌活性科学出版物

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> Miliusa plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. There have been a few previously reports on the chemical constituents of plants in this genus, describing the presence of aporphine alkaloids, terpenoids, flavonoids, phenylpropanoids, styrylpyrones, bis-styryls and homogentisic acid derivatives. Miliusa smithiae, a new species for Thailand and world, has not been studied chemical composition. The present study described phytochemical study of the leaves and twigs of M. smithiae together with their cytotoxicity. The M. smithiae was selected and percolated with hexane, ethyl acetate, acetone and methanol. The extracts were purified and elucidated chemical structures. The constituent of ethyl acetate extract of M. smithiae has been investigated. We isolated and identified two flavonoid derivatives, 5-hydroxy-3,7,4?-trimetoxyflavone (1) and 5,3?-dihydroxy-3,7,4?-trimetoxyflavone (2). The structures of these compounds were elucidated on the basis of spectroscopic evidence. Studies on ethyl acetate extract of M. smithiae has now resulted the isolation and structural characterization of two flavonoids. Their anticancer activities were evaluated using SRB assays. In this method, compound 2 showed potential activity in cell lines.
机译： > Miliusa 属于番荔枝科的植物在泰国发现，并已被用作泰国的传统药物。先前已经有关于该属植物的化学成分的一些报道，描述了吗啡碱生物碱，萜类化合物，类黄酮，苯基丙烷，苯乙烯基吡喃酮，双-苯乙烯基和高纯酸衍生物的存在。 Miliusa smithiae 是泰国和世界的新物种，尚未研究其化学成分。本研究描述了 M的叶子和细枝的植物化学研究。铁匠及其细胞毒性。 M。选择铁匠铺并用己烷，乙酸乙酯，丙酮和甲醇渗透。提取物经过纯化并阐明了化学结构。 M的乙酸乙酯提取物的成分。铁匠铺已被调查。我们分离并鉴定出两种类黄酮衍生物，即5-羟基-3,7,4′-三甲氧基黄酮（1）和5，3′-二羟基-3,7,4′-三甲氧基黄酮（2）。根据光谱证据阐明了这些化合物的结构。 M的乙酸乙酯提取物的研究。 smithiae 现在导致了两种黄酮的分离和结构表征。使用SRB分析评估其抗癌活性。在该方法中，化合物2在细胞系中显示出潜在的活性。

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