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首页> 外文期刊>American journal of applied sciences >The Effect of a Prophylactic Dose of Ibuprofen on Plasma Level of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-Alpha in a 1500 m Running Practice | Science Publications
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The Effect of a Prophylactic Dose of Ibuprofen on Plasma Level of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-Alpha in a 1500 m Running Practice | Science Publications

机译：预防性剂量布洛芬对1500 m跑步实践中血浆白细胞介素1，白细胞介素6和肿瘤坏死因子-α水平的影响|科学出版物

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> >Problem statement: there are controversies about the effects of anti-inflammatory drugs on exercised induced changes on plasma cytokines in untrained male athletes, so the primary purpose of this study was to measure the influence of a prophylactic dose of ibuprofen use on plasma cytokines during a 1500 m running race. >Approach: Subjects were 10 untrained male Medical University students who consumed 400 mg ibuprofen two hours before the 1500 m running practice and 10 controls that competed in the race but avoided ibuprofen and all other medications. Blood samples were collected before, 1h and 24 h following the 1500 m exercise bout to measure plasma concentrations of interleukin-1 beta (IL-1β ), interleukin-6(IL-6) and tumor necrosis factor alpha (TNF- α ). >Results: There were not any significant differences between plasma concentration of IL-1β, IL-6 and TNF- α during the study period. Also the data showed that there were not any significant differences between plasma level of IL-1β, IL-6 and TNF- α in ibuprofen and control group during the study period. >Conclusions/Recommendation: Our result showed that a prophylactic dose of ibuprofen did not affect acute inflammatory cytokines levels (IL-1β, IL-6 and TNF- α) in untrained healthy young males. So the etiology of the muscle soreness in athletes actively participating in sport races seems to be independent of inflammatory processes.
机译： > >问题陈述：关于在未训练的男运动员中抗炎药对运动诱发的血浆细胞因子变化的影响尚存争议，因此本研究的主要目的是测量在1500 m跑步比赛中预防剂量的布洛芬对血浆细胞因子的影响。 >方法：对象是10名未经训练的男医科大学学生，他们在1500 m跑步练习前两个小时服用了400 mg布洛芬，还有10名参加比赛但未使用布洛芬和所有其他药物的对照组。在1500 m运动周期之前，之后1h和24h采集血样，以测量白细胞介素1β（IL-1β），白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）的血浆浓度。 >结果：在研究期间，IL-1β，IL-6和TNF-α的血浆浓度之间没有任何显着差异。数据还表明，在研究期间，布洛芬和对照组的IL-1β，IL-6和TNF-α的血浆水平没有显着差异。 >结论/建议：我们的结果表明，在未经训练的健康年轻男性中，预防剂量的布洛芬不会影响急性炎症细胞因子水平（IL-1β，IL-6和TNF-α）。因此，积极参加运动比赛的运动员的肌肉酸痛的病因似乎与炎症过程无关。

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