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首页> 外文期刊>American journal of applied sciences >A New Proposed Statistically-Derived Compromise Cut-off CD4 Count Value for HIV Patients to Start using ARVs | Science Publications
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A New Proposed Statistically-Derived Compromise Cut-off CD4 Count Value for HIV Patients to Start using ARVs | Science Publications

机译：HIV患者开始使用抗逆转录病毒药物的一项新的统计上建议的折中临界CD4计数值科学出版物

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> >The study investigated the relationship between statistical outliers and the inconsistent values of the CD4 count recommended for starting the Antiretroviral Therapy (ART) by HIV-positive patients. Low CD4 counts imply a low immune system. It could be due to AIDS existence or closeness to death. An effective treatment to curb HIV impact is ART, which is recommended for low CD4 counts. However, countries differ in the values used. Developed nations recommend start of ART when the CD4 is still high in order to curb its development. Poor countries use very low CD4 counts. Some countries keep changing the CD4 value for this purpose. The problem is that when CD4 counts are too low, HIV may already be too advanced, making it difficult to save the patient from progression to full AIDS. There should be CD4 values derived using scientific methods to assist in standardizing the CD4 count value for ART commencement. Using a retrospective single-site cohort study design, the study analyses the CD4 counts using robust statistical methods together with conventional statistical methods to study outliers and then derive a compromise CD4 count value that could serve as the standard cut-off starting point for using ART. The CD4 count confidence limits showed outliers to be above 300 cells/mm3. The lower bound of 0 cannot happen to any living person. The 300 upper bound is a value within the manageable outliers that has not reached critical HIV state. However, this value is near risky CD4 count values. The CD4 count of 300cells/mm3 indicates deteriorating HIV. If it is set as the starting point of taking ARVs, the patients involved can be saved from reaching painful states of lower CD4 counts.HIV patients’ immune systems at this level can still be boosted without them showing physical weakness from eye inspection.
机译： > >该研究调查了统计异常值与HIV阳性患者推荐用于开始抗逆转录病毒疗法（ART）的CD4计数不一致值之间的关系。 CD4计数低意味着免疫系统低。这可能是由于艾滋病的存在或接近死亡。抑制艾滋病毒影响的有效方法是抗逆转录病毒疗法，建议将其用于低CD4计数。但是，各国使用的值不同。发达国家建议在CD4仍然很高时开始抗病毒治疗，以遏制其发展。贫穷国家使用的CD4数量很少。一些国家为此目的不断更改CD4的值。问题在于，当CD4计数过低时，HIV可能已经过高，难以使患者免于发展为完全AIDS。应该使用科学方法得出CD4值，以帮助标准化抗病毒治疗的CD4计数值。使用回顾性单中心队列研究设计，该研究使用可靠的统计方法和常规统计方法分析CD4计数，以研究异常值，然后得出折衷的CD4计数值，可以作为使用ART的标准起点。 CD4计数置信极限显示异常值高于300个/ mm3。下限0不可能发生在任何活着的人身上。 300上限是在可控制的异常值范围内的值，尚未达到关键的HIV状态。但是，该值接近危险的CD4计数值。 CD4计数为300cells / mm 3 表明HIV恶化。如果将其作为服用抗逆转录病毒药物的起点，则可以避免所涉及的患者陷入CD4计数较低的痛苦状态。在这种水平下，艾滋病毒患者的免疫系统仍可以得到增强，而他们不会因眼检而表现出身体虚弱。

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