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首页> 外文期刊>American journal of applied sciences >The Physiological Effects on Hormones levels and Kidneys Functions Induced by The Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs | Science Publications
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The Physiological Effects on Hormones levels and Kidneys Functions Induced by The Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs | Science Publications

机译：合成代谢雄性激素药物（Sustanon）对雄性豚鼠的激素水平和肾脏功能的生理影响科学出版物

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> Problem statement: In recent years, the intentional abuse of anabolic androgenic drugs by athletes has increased rapidly in many countries to become a serious negative phenomenon. Athletes, specially in power sports, abuse these drugs such as Sustanon in high doses to obtain a rapid and huge increasing in the muscles mass and to improve their performance during the sport competitions. This abuse causes severe adverse effects among the abusers. Approach: The present physiological study was performed to answer the following question: could Sustanon abuse induce marked abnormal alterations in some hormones levels and in the kidneys functions?. The current study was needed due to the lack of sufficient information about the hormonal and nephritic adverse effects caused by Sustanon abuse in particular. This study on male Guinea pigs aimed to investigate the potential abnormal alterations in the levels of some hormones and in the kidney functions induced by repeated administration of two Sustanon doses. The treated animals were injected intramuscularly (i.m.) once a week with Sustanon doses as follow (15 mg Kg-1 in group G II and 30 mg Kg-1 in group G III) for a continuous treatment period of 6 weeks. Results: The results of the blood biochemical measurements showed statistical significant decreases in means of the serum levels of: Triiodothyronine (TT3), Thyroxine (TT4) and Insulin specially in the treated group (G III) (0.42
机译： > 问题陈述：近年来，运动员故意滥用合成代谢雄激素药物在许多国家迅速增加，已成为严重的负面现象。特别是在强力运动中，运动员滥用高剂量的Sustanon等药物，以使肌肉质量迅速大量增加，并在运动比赛中改善其性能。这种滥用在滥用者中造成严重的不利影响。 方法：目前进行的生理学研究回答了以下问题：Sustanon滥用会引起某些激素水平和肾脏功能的明显异常改变吗？由于缺乏有关Sustanon滥用引起的激素和肾病不良反应的足够信息，因此需要进行当前研究。这项关于雄性豚鼠的研究旨在研究重复服用两次Sustanon剂量可能引起的某些激素水平和肾脏功能的潜在异常改变。每周对肌肉注射一次（im）的Sustanon剂量（G II组为15 mg Kg -1 ，G组为30 mg Kg -1 III）连续治疗6周。 结果：血液生化测量结果显示，在治疗组（G III）中，三碘甲状腺素（TT3），甲状腺素（TT4）和胰岛素的血清水平显着下降（0.42）

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