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首页> 外文期刊>American journal of applied sciences >Moringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral Ischemia | Science Publications
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Moringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral Ischemia | Science Publications

机译：辣木潜藏减轻局灶性脑缺血的氧化损伤和脑梗死体积科学出版物

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> Problem statement: At present, the therapeutic outcome of cerebral ischemia is still not in the satisfaction level. Therefore, the preventive strategy is considered. Based on the protective effect against oxidative damage of Moringa oleifera Lam. Leaves extract, we hypothesized that this plant extract might protect against cerebral ischemia, one of the challenge problems nowadays. In order to test this hypothesis, we aimed to determine the protective effect of M.oleifera leaves extract in animal model of focal cerebral ischemia induced by permanent occlusion of right middle cerebral artery. Approach: Male Wistar rats, weighing 300-350 g, were orally given the extract once daily at doses of 100, 200 and 400 mg kg-1 BW at a period of 2 weeks, then, they were permanently occluded the right Middle Cerebral Artery (MCAO). The animals were assessed the cerebral infarction volume and oxidative damage markers including MDA level and the activities of SOD, CAT and GSHPx enzymes at 24 h after occlusion. Results: Rats subjected to M.oleifera extract at all doses used in this study significantly decreased brain infarct volume both at cortical and subcortical structures in accompany with the elevation of SOD activity in both hippocampus and striatum while only the rats exposed to the extract at doses of 100 and 400 mg kg-1 BW showed the increased GSHPx activity in hippocampus. No the changes were observed. Therefore, our results demonstrates the potential benefit of M.oleifera leaves to decrease oxidative stress damage and brain infarct volume. Conclusion: This study is the first study to demonstrate the neuroprotective effect against focal cerebral ischemia of M.oleifera leaves. It suggests that M.oleifera may be served as natural resource for developing neuroprotectant against focal cerebral ischemia. However, the precise underlying mechanism and possible active ingredient are still required further study.
机译： > 问题陈述：目前，脑缺血的治疗结果仍未达到满意水平。因此，应考虑预防策略。基于对油桐的氧化损伤的保护作用。叶提取物，我们假设这种植物提取物可以预防脑缺血，这是当今的挑战性问题之一。为了检验该假设，我们旨在确定油松叶提取物在右中脑动脉永久性阻塞所致局灶性脑缺血动物模型中的保护作用。 方法：雄性Wistar大鼠，体重300-350 g，每天口服一次提取物，剂量为100、200和400 mg kg -1 BW，持续时间为200公斤。 2周后，他们被永久性地阻塞了右脑中动脉（MCAO）。在闭塞后24小时，评估动物的脑梗死体积和氧化损伤标志物，包括MDA水平以及SOD，CAT和GSHPx酶的活性。 结果：在本研究中使用所有剂量的油茶提取物的大鼠均显着减少了皮质和皮质下结构的脑梗塞体积，并伴有SOD活性的升高。海马和纹状体均如此，而仅暴露于100和400 mg kg -1 BW的提取物的大鼠海马中的GSHPx活性增加。没有观察到变化。因此，我们的结果证明了 M.oleifera 叶片对减少氧化应激损伤和脑梗死体积的潜在益处。 结论：该研究是首次证明对油茶叶片的局灶性脑缺血的神经保护作用。提示 oleifera 可以作为开发抗局灶性脑缺血神经保护剂的天然资源。但是，确切的潜在机理和可能的活性成分仍需要进一步研究。

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