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Strategizing the Development of Alzheimer’s Therapeutics

机译：战略制定阿尔茨海默氏症治疗学

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Alzheimer’s Disease is a complex, progressive condition with symptoms that do not reveal themselves until significant changes to neuronal morphology have already occurred. The delayed manifestation of cognitive decline makes determination of the true etiological origins difficult. As a result, identification of ideal drug targets becomes seemingly impossible. The existing treatments for Alzheimer’s Disease may temporarily suppress the rate of cognitive decline, but do little to slow or halt neuronal decay. While many believe that the current approaches to identifying a cure for the disease are too narrow-minded, focusing heavily on the physical manifestations of the diseased brain such as amyloid plaques and neurofibrillary tangles, this review asserts the status of Alzheimer’s research as rational and multi-faceted.
机译：阿尔茨海默氏病是一种复杂的进行性疾病，其症状只有在神经元形态发生重大变化后才会显现出来。认知功能减退的延迟表现使得确定真正病因的难度很大。结果，理想药物靶标的鉴定似乎变得不可能。现有的阿尔茨海默氏病治疗方法可能会暂时抑制认知能力下降的速度，但对延缓或阻止神经元衰退的作用不大。尽管许多人认为目前确定该病治愈方法的方法过于狭narrow，但主要关注患病大脑的物理表现，如淀粉样斑块和神经原纤维缠结，但这项综述断言了阿尔茨海默氏症研究的合理性和多重性。多面的。

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