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首页> 外文期刊>American journal of applied sciences >Prophylactic Effects of Melatonin on Sodium Valproate-Induced Neural Tube Defects and Skeletal Malformations in Rat Embryos | Science Publications
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Prophylactic Effects of Melatonin on Sodium Valproate-Induced Neural Tube Defects and Skeletal Malformations in Rat Embryos | Science Publications

机译：褪黑素对丙戊酸钠诱发的大鼠胚胎神经管畸形和骨骼畸形的预防作用科学出版物

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> Problem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregnant rats that were divided into five groups. Control group received normal saline and test groups received sodium valproate (300 mg kg?1), sodium valproate (300 mg kg?1) plus melatonin (5 mg kg?1) and sodium valproate (300 mg kg?1) plus melatonin (10 mg kg?1) and melatonin (10 mg kg?1), intraperitonealy at 8-9th days of gestation, respectively. Fetuses were collected at 20th day of gestation and after determination of weight and length; they were stained by Alizarin red-Alcian blue method. Results: Cleft palate, spina bifida and exencephaly incidence were 17.70, 20 and 20% in fetuses of rats that received only sodium valproate. Cleft palate, spina bifida and exencephaly incidence were 4.16, 8.33 and 8.33% range in group which received sodium valproate plus melatonin (5 mg kg?1), respectively. However, Cleft palate, spina bifida and excencaphaly incidence were 4/76, 0 and 0% in group which received sodium valproate plus melatonin (10 mg kg?1), respectively. The mean of weight and length of animals fetuses that received melatonin were significantly greater than those received only sodium valproate. Conclusion: It is concluded that melatonin with dose of 10 mg kg?1 had significantly more prophylactic effect than melatonin with dose of 5 mg kg?1 on incidence of sodium valproate-induced skeletal malformations.
机译： > 问题陈述：一些报告表明，通过使用抗氧化剂和刺激母体免疫系统可以预防丙戊酸钠的致畸作用。因此，在这项研究中，比较了褪黑激素对丙戊酸钠致畸作用的预防作用。 方法：这项研究是针对31只怀孕的大鼠进行的，将其分为五组。对照组接受生理盐水，测试组接受丙戊酸钠（300 mg kg 1 ），丙戊酸钠（300 mg kg 1 ）加褪黑激素（5 mg kg ） >？1 ）和丙戊酸钠（300 mg kg ？1 ）加上褪黑激素（10 mg kg ？1 ）和褪黑激素（10 mg kg ？1 ），分别在妊娠第8-9天腹膜内进行。在妊娠第20天和确定体重和身长后收集胎儿;它们被茜素红-阿尔辛蓝法染色。 结果：仅接受丙戊酸钠大鼠的胎儿的C裂，脊柱裂和脑电图发病率分别为17.70％，20％和20％。接受丙戊酸钠加褪黑激素（5 mg kg 1 ）治疗的组的pa裂，脊柱裂和脑脊液的发生率分别为4.16％，8.33％和8.33％。然而，接受丙戊酸钠加褪黑激素（10 mg kg？1）治疗的组的C裂，脊柱裂和椎弓根的发生率分别为4 / 76、0和0％。接受褪黑激素的动物胎儿的体重和身长的平均值明显大于仅接受丙戊酸钠的动物。 结论：结论是，剂量为10 mg kg ？1 的褪黑素比剂量为5 mg kg？ 1 关于丙戊酸钠引起的骨骼畸形的发生率。

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