...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Analytical Chemistry >Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes
【24h】

Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes

机译：基于PVC和Sol-Gel膜的电位检测器对药物中的氨苄西林进行顺序注射分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This work describes the construction and the evaluation of the general performance of new ampicilli-nate-selective electrodes based on manganese (III) tetraphenylporphyrin [Mn(III) TPP-Cl] as ionophore, incorporated in both PVC and sol-gel membranes and directly applied onto a conductive graphite/epoxy resin support. The units were constructed without inner reference solution adopting conventional configuration and in the case of PVC membrane the tubular configuration was also adopted. The good working characteristics of these electrodes, made possible its application to the determination of ampicillin in pharmaceuticals formulations, both in conventional batch analysis and in flow conditions, when the electrodes were coupled to a SIA system. In the last case the potentiometric sensors presented linear response towards ampicillin concentration between 5.0 × 10–4 and 5.0 × 10–2 mol?l–1 with slopes of –57.4 and –63.5 mV?dec–1 for the PVC and sol-gel membranes, respectively. The developed procedures enable mean relative standard deviations better than 3% for all the samples analysed. The obtained results do not statistically differ from those furnished by applying the HPLC reference method.
机译：这项工作描述了基于锰（III）四苯基卟啉[Mn（III）TPP-Cl]作为离子载体的新型氨苄盐酸盐选择性电极的构建和一般性能的评估，该电极既可直接引入PVC膜，也可直接进入溶胶-凝胶膜应用于导电石墨/环氧树脂载体上。这些单元的构造没有采用常规配置的内部参考溶液，在PVC膜的情况下，也采用了管状配置。这些电极的良好工作特性使其有可能应用于常规批次分析和流动条件下（当电极与SIA系统耦合时）测定药物制剂中的氨苄青霉素。在最后一种情况下，电位传感器对氨苄青霉素浓度在5.0×10–4和5.0×10–2 mol？l–1之间呈现线性响应，PVC和溶胶-凝胶的斜率分别为–57.4和–63.5 mV？dec-1。膜。对于所有分析样品，开发的程序可使平均相对标准偏差优于3％。获得的结果与采用HPLC参考方法提供的结果在统计上没有差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号