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首页> 外文期刊>American journal of applied sciences >Moringa oleifera Leaves Extract Attenuates Neuropathic Pain Induced by Chronic Constriction Injury | Science Publications
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Moringa oleifera Leaves Extract Attenuates Neuropathic Pain Induced by Chronic Constriction Injury | Science Publications

机译：辣木叶提取物减轻慢性收缩损伤所致的神经性疼痛科学出版物

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> >Problem statement: Neuropathic pain, a challenge of this decade, has been reported to be associated with the diversity conditions including diabetes. At present, there are no conventional analgesics that can effectively treat neuropathic pain with a satisfactory outcome. Due to the limitation of therapeutic efficacy, the searching for novel effective remedies in the management of neuropathic pain is required. >Approach: Male Wistar rats, weighing 180-220 g were induced diabetes mellitus by Streptozotocin (STZ) (single injection, 65 mg kg-1 BW, i.p). Diabetic rats were induced neuropathic pain by Constricting the right sciatic nerve (CCI) at permanently. Then, all rats were administered the extract of M. oleifera leaves at doses of 100, 200 and 300 mg kg-1 BW once daily in a period of 21 days. The analgesic effect of the plant extract was evaluated using Von Frey filament and hot plate tests every 3 days after CCI throughout 21-day experimental period. In addition, at the end of the experiment, the alteration of oxidative damage markers including MDA level and the activities of SOD, CAT and GSH-PX in the injured sciatic nerve were also evaluated. >Results: The current results showed that rats subjected to M.oleifera leaves extract at doses of 100 and 200 mg kg-1 BW significantly reversed the decreased withdrawal threshold intensity and withdrawal latency in Von Frey filament and hot plate tests respectively. In addition, rats subjected to the medium dose extract also reversed the decreased activities of SOD and GSH-Px and the elevation of MDA level in the injured nerve. Taken all together, our data suggest that M. oleifera leaves extract can attenuate neuropathic pain in diabetic condition. The possible underlying mechanism may occur partly via the decreased oxidative stress. However, other mechanisms may also involve. >Conclusion: Our results suggest that M. oleifera leaves may be the potential novel adjuvant therapy for neuropathic pain management.
机译： > >问题陈述：据报道，这是近十年来的神经病性疼痛，与包括糖尿病在内的多种疾病有关。目前，尚无常规镇痛药能有效治疗神经痛并取得令人满意的结果。由于治疗功效的限制，需要寻找治疗神经性疼痛的新的有效疗法。 >方法：链脲佐菌素（STZ）（单剂量65 mg kg -1 BW，腹腔注射）诱导雄性Wistar大鼠体重180-220 g。糖尿病大鼠通过永久性地收缩右坐骨神经（CCI）诱发神经性疼痛。然后，向所有大鼠施用 M的提取物。油菜叶在21天内每天以100、200和300 mg kg -1 BW的剂量离开。在整个21天的实验期间，CCI后每3天使用Von Frey细丝和热板测试评估植物提取物的镇痛效果。另外，在实验结束时，还评估了损伤的坐骨神经中包括MDA水平在内的氧化损伤标志物的变化以及SOD，CAT和GSH-PX的活性。 >结果：目前的结果表明，接受 M.oleifera 叶提取物的大鼠的BW剂量分别为100和200 mg kg -1 分别降低了冯·弗雷丝和热板测试的退出阈值强度和退出潜伏期。此外，接受中等剂量提取物的大鼠还可以逆转受损神经中SOD和GSH-Px活性降低以及MDA水平升高。综上所述，我们的数据表明 M。油橄榄叶提取物可以减轻糖尿病患者的神经性疼痛。潜在的潜在机制可能部分通过降低的氧化应激而发生。但是，其他机制也可能涉及。 >结论：我们的结果表明 M。油茶叶可能是潜在的新型神经痛治疗辅助疗法。

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