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首页> 外文期刊>American Journal of Analytical Chemistry >Analysis of Cocaine and Crack Cocaine via Thin Layer Chromatography Coupled to Easy Ambient Sonic-Spray Ionization Mass Spectrometry
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Analysis of Cocaine and Crack Cocaine via Thin Layer Chromatography Coupled to Easy Ambient Sonic-Spray Ionization Mass Spectrometry

机译：薄层色谱结合简易环境声波喷雾电离质谱分析可卡因和可卡因

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摘要

Cocaine and crack cocaine are usually seized with a great diversity of adulterants, such as benzocaine, lidocaine, caffeine, and procaine. The forensic identification of cocaine in these drug mixtures is normally performed using colorimetric testing kits, but these tests may suffer from interferences providing false-positive or false-negatives. In this work, we describe the use of thin layer chromatography coupled to easy sonic-spray ambient ionization mass spectrometry (TLC/EASI-MS) for rapid and secure analysis of cocaine and crack cocaine. Fifteen cocaine samples were analyzed, and all of them revealed positive TLC/EASI-MS results for cocaine, but other drugs and adulterants were also detected such as lidocaine, caffeine, benzocaine, lactose, benzoylecgonine, and ecgonidine. False positives and false negatives, as judged by the TLC Rf values, were identified via on-spot characterization by EASI-MS. The TLC/EASI-MS combination seems therefore to provide an appropriate technique for secure forensic investigations of illicit drugs.
机译：可卡因和可卡因通常带有各种掺假剂，例如苯佐卡因，利多卡因，咖啡因和普鲁卡因。通常使用比色检测试剂盒对这些药物混合物中的可卡因进行法医鉴定，但是这些检测可能会受到干扰，导致假阳性或假阴性。在这项工作中，我们描述了薄层色谱法与易爆声环境离子化质谱法（TLC / EASI-MS）的结合使用，可快速，安全地分析可卡因和可卡因。分析了15个可卡因样品，所有样品均显示可卡因TLC / EASI-MS结果呈阳性，但还检出了其他药物和掺假品，如利多卡因，咖啡因，苯佐卡因，乳糖，苯甲酰芽子碱和芽子定。通过EASI-MS通过现场表征鉴定出由TLC Rf值判断出的假阳性和假阴性。因此，TLC / EASI-MS组合似乎为安全地对非法药物进行法医调查提供了一种适当的技术。

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