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首页> 外文期刊>American journal of applied sciences >TUMOR NECROSIS FACTOR-ALPHA AS BIOMARKERS OF EXPOSURE TO INDOOR POLLUTANTS AMONG PRIMARY SCHOOL CHILDREN IN KLANG VALLEY | Science Publications
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TUMOR NECROSIS FACTOR-ALPHA AS BIOMARKERS OF EXPOSURE TO INDOOR POLLUTANTS AMONG PRIMARY SCHOOL CHILDREN IN KLANG VALLEY | Science Publications

机译：肿瘤坏死因子-α作为喀琅河谷小学儿童室内污染物暴露的生物标志物科学出版物

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> Poor indoor air quality can be particularly harmful to children and interfere with the growth of their lung function as they spend much of their time indoors. In order to understand the mechanism of exposure in the airways, biomarkers were used as a surrogate for biological responses towards indoor air pollutants. This study aims to investigate the association between indoor air pollutants (PM2.5, PM10 and NO2) among school children in different area of urban and rural site in Klang Valley. A cross sectional comparative study was conducted among 430 healthy schoolchildren from a national primary school. Methods involved questionnaires based on American Thoracic Society and sputum samples for biomarkers assay. Indoor exposure to PM2.5 and PM10 (Dust Trak Aerosol Monitor) and NO2 (LaMotte Air Sampler) were measured in the classroom. Mean concentration of PM2.5 (50.72 μg/m3) in urban schools were significantly higher compared to rural (28.36 μg/m3) school. Similar trend found in indoor level of PM10 in urban and rural schools with 87.04 μg/m3 and 56.76 μg/m3 respectively. The mean exposure level of NO2 of urban schools (0.12 ppm) is nearly 4 times higher than the level in rural areas (0.032 ppm). A significant association was found between indoor air concentrations (PM2.5 and PM10) with TNF-alpha level. Children from rural areas are exposed to less air pollutants compared to those from urban area and this study also suggests that higher exposure to PM2.5, PM10 and NO2 are associated with increasing of TNF-alpha level.
机译： >室内空气质量差对儿童尤其有害，并且由于他们在室内花费大量时间，因此会干扰他们的肺功能增长。为了了解在空气中暴露的机制，生物标志物被用作对室内空气污染物的生物反应的替代物。本研究旨在调查室内空气污染物（PM 2 。 5 ，PM 10 和NO 2 ）在巴生谷市区和农村地区不同地区的学童中。在430名来自国立小学的健康学童中进行了横断面比较研究。方法包括基于美国胸科学会的问卷和用于生物标志物测定的痰液样本。在教室中测量室内暴露于PM 2.5 和PM 10 （尘埃气溶胶监测仪）和NO 2 （LaMotte空气采样器）的情况。城市学校PM 2.5 （50.72μg/ m 3 ）的平均浓度显着高于农村学校（28.36μg/ m 3 ）的学校。城乡学校的室内PM 10 水平相似，分别为87.04μg/ m 3 和56.76μg/ m 3 。城市学校NO 2 的平均暴露水平（0.12 ppm）几乎是农村地区（0.032 ppm）的4倍。发现室内空气浓度（PM 2.5 和PM 10 ）与TNF-α水平显着相关。与城市地区的儿童相比，农村地区的儿童暴露于较少的空气污染物中，该研究还表明，PM 2.5 ，PM 10 和NO 2的暴露量较高。 与TNF-α水平升高有关。

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