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首页> 外文期刊>American Journal of Analytical Chemistry >Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines
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Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

机译：总误差策略在可负担和可及的紫外可见分光光度法验证不良药品质量控制中的应用

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摘要

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.
机译：在使用在这些国家容易获得的经典分析方法与在发展中国家销售的劣质药物进行斗争的框架中，针对一种抗疟药（奎宁）和两种抗生素（阿莫西林和甲硝唑）开发并验证了四种紫外可见分光光度法使用精度配置文件作为决策工具确定总误差策略。剂量范围为2-10μg/ mL（对于片剂中的硫酸奎宁），4-12μg/ mL（对于口服滴剂中的二氯奎宁-口服悬浮液的甲硝唑苯甲酸酯）和15-35μg/ mL（对于阿莫西林三水合物，胶囊）。然后将经过验证的方法用于确定在刚果民主共和国出售的某些类似药物的含量。因此，建议的紫外可见分光光度法简便易行，适合定量不同药物形式的奎宁，阿莫西林和甲硝唑。

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