...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Analytical Chemistry >Use of Graphene and Cucurbit[7]uril Electrodes for the Determination of Amantadine in Biological Fluids
【24h】

Use of Graphene and Cucurbit[7]uril Electrodes for the Determination of Amantadine in Biological Fluids

机译：石墨烯和葫芦[7]尿素电极在生物液体中金刚烷胺的测定

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A differential pulse voltammetry (DPV) method for amantadine (AT) determination is developed. To this end, all the chemical and instrumental variables affecting the determination of amantadine are optimized. These studies have used three types of glassy-carbon electrode, first electrode which has not undergone surface modification or coating, to then modify the working electrode surface with two kinds of suspensions: graphene and graphene-cucurbit[7]uril (CB[7]). From studies of the mechanisms governing the electrochemical response of amantadine, it was concluded that it is an electrochemically system with a diffusive reduction phenomenon. Under optimal conditions and with the appropriate electrode modification, we proceed to study the relation between the peak intensity with the analyte concentration. Thus, we find that when the electrode surface is covered with graphene-CB[7], two linear sections are obtained, the first one in the concentration range of between 0.05 μg·mL﹣1 and 0.75 μg·mL﹣1 ; and the second one between 1.00 μg·mL﹣1 and 6.00 μg·mL﹣1, with Er (%) = 87 and R.S.D. = 0.94% (n = 10 at 0.5 μg·mL﹣1 level). The minimum detectable amount was 15 ng·mL﹣1 while a concentration of 44 ng·mL﹣1 was calculated as determination limit. The optimized method was applied to the determination of amantadine in biological fluids.
机译：建立了金刚烷胺（AT）测定的差分脉冲伏安法（DPV）。为此，优化了影响金刚烷胺测定的所有化学和仪器变量。这些研究使用了三种类型的玻璃碳电极，第一种未经表面改性或涂层的电极，然后用两种悬浮液对工作电极表面进行改性：石墨烯和石墨烯-葫芦[7] uril（CB [7] ）。通过研究金刚烷胺的电化学反应机理，可以得出结论，这是一个具有扩散还原现象的电化学系统。在最佳条件下和适当的电极修饰下，我们继续研究峰强度与分析物浓度之间的关系。因此，我们发现当电极表面覆盖有石墨烯-CB [7]时，获得了两个线性部分，第一个线性部分的浓度范围为0.05μg·mL﹣1至0.75μg·mL﹣1;第二个在1.00μg·mL﹣1和6.00μg·mL﹣1之间，Er（％）= 87，R.S.D。 ＝ 0.94％（在0.5μg·mL×1水平下n ＝ 10）。最低检测量为15 ng·mL﹣1，计算出浓度为44 ng·mL﹣1作为测定极限。优化后的方法用于生物流体中金刚烷胺的测定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号