• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta anaesthesiologica Taiwanica : >Clinical study to evaluate the role of preoperative dexmedetomidine in attenuation of hemodynamic response to direct laryngoscopy and tracheal intubation
【24h】

Clinical study to evaluate the role of preoperative dexmedetomidine in attenuation of hemodynamic response to direct laryngoscopy and tracheal intubation

机译：评估术前右美托咪定在减轻直接喉镜和气管插管对血流动力学反应中的作用的临床研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: Dexmedetomidine, an @a2 agonist, has been evaluated for its hypnotic, analgesic, and anxiolytic properties in the intraoperative period and critical care setting. However, data on the effect of dexmedetomidine on attenuation of pressor response to direct laryngoscopy and tracheal intubation are limited. We studied the effect of a single preinduction intravenous dose of dexmedetomidine of 0.5 @mg/kg on hemodynamic responses to tracheal intubation, and dose requirements of anesthetics for induction and their adverse effects. Methods: Eighty adult patients scheduled for elective surgery under general anesthesia requiring tracheal intubation were included. Patients were randomized into two groups: dexmedetomidine and placebo (n = 40 each). The study drug was administered intravenously over a period of 10 minutes prior to induction. Direct laryngoscopy and endotracheal intubation were performed. Hemodynamic parameters, the total dose of propofol, and adverse effects were recorded during induction and postintubation periods for 15 minutes. Results: The maximum percentage increase in the heart rate after intubation was 19.6% less in the dexmedetomidine group than that in the placebo group (12.96% vs. 32.57%). The maximum percentage increases in systolic blood pressure, diastolic blood pressure, and mean blood pressure after intubation were significantly lower in the dexmedetomidine group than in the placebo group (12.38% vs. 45.63%, 19.36% vs. 60.36%, and 15.34% vs. 50.33%, respectively). There was a significant reduction of the mean total dose of propofol required for induction, 1.04 mg/kg in the dexmedetomidine group versus 2.01 mg/kg in the placebo group (p < 0.001). No serious side effects or adverse reactions were observed in either group. Conclusion: Administration of a single preinduction intravenous dose of dexmedetomidine of 0.5 @mg/kg resulted in significant attenuation of the rise in the heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure, until 5 minutes postintubation. It significantly reduced the dose requirements of propofol for induction and caused minimal side effects.
机译：目的：已对@ a2激动剂右美托咪定在术中和重症监护环境中的催眠，镇痛和抗焦虑特性进行了评估。然而，关于右美托咪定对直接喉镜和气管插管的升压反应减弱作用的数据有限。我们研究了0.5 mg / kg的单次诱导前静脉注射右美托咪定对气管插管的血流动力学反应的影响，以及麻醉药诱导剂量的要求及其不利影响。方法：纳入80例行全身麻醉，需要行气管插管的择期手术的成年患者。将患者随机分为两组：右美托咪定和安慰剂（每组n = 40）。诱导前10分钟内静脉内给予研究药物。进行直接喉镜检查和气管插管。在诱导和插管后15分钟内记录血流动力学参数，丙泊酚的总剂量以及不良反应。结果：右美托咪定组插管后心率的最大增加百分比比安慰剂组少19.6％（12.96％对32.57％）。右美托咪定组的收缩压，舒张压和插管后平均血压的最大增加百分比显着低于安慰剂组（分别为12.38％，45.63％，19.36％，60.36％和15.34％。 50.33％）。诱导所需的异丙酚平均总剂量显着降低，右美托咪定组为1.04 mg / kg，而安慰剂组为2.01 mg / kg（p <0.001）。两组均未观察到严重的副作用或不良反应。结论：插管前5分钟，单次诱导前静脉注射右美托咪定0.5 @ mg / kg可显着降低心率，收缩压，舒张压和平均血压的升高。它显着降低了异丙酚诱导所需的剂量，并引起最小的副作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号