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首页> 外文期刊>American Journal of Drug Discovery and Development >Antigout and Antioxidant Activity of Stem and Root of Origanum majorana Linn.
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Antigout and Antioxidant Activity of Stem and Root of Origanum majorana Linn.

机译：牛至的茎和根的抗痛风和抗氧化活性。

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The present study was aimed at investigating the antioxidant and antigout activity of the various extracts of the stem and root of Origanum majorana Linn. The antioxidant activity of ethanol extracts of both stem and root of marjoram was evaluated by various in vitro antioxidant assays. The ethanol extracts of stem and root showed potent antioxidant activity in all models when compared with ascorbic acid having IC50 values 21.05 μg mL-1 and 84.98 μg mL-1 for DPPH (2, 2-diphenyl-picrylhydrazyl); 492.8 μg mL-1 and 477.6 μg mL-1 for H2O2 radical scavenging assay; 156.9 and 141.79 μg mL-1 for metal chelating assay, respectively. The reducing ability of root ethanol extract (absorbance 0.747±0.23) was found to be high, compared to stem ethanol extract (0.527±0.14). The in vitro xanthine oxidase inhibitory activity was performed on ethanol and aqueous extracts (stem and root) of the plant and activity was found to be significant with IC50 59.21 and 148 μg mL-1 in both ethanol extracts. Further in-vivo antigout was studied gout induced in rats. Oral administration of stem and root ethanol extracts (200 and 400 mg kg-1 body weight) showed a significant decrease in uric acid, Creatinine, ESR (Erythrocyte Sedimentation Rate) and MDA (Malondialdehyde) levels in the gouty rats. A significant increase was observed in reduced glutathione. No change in protein content was noticed. In conclusion, the studied plant extracts showed significantly variable anti-gout activity associated with both antioxidant and anti-inflammatory effects which may be due to the presence of flavonoids, phenolics, saponins and triterpenoidal compounds revealed by preliminary phytochemical screening.
机译：本研究旨在调查牛至牛至茎和根的各种提取物的抗氧化和抗痛风活性。通过各种体外抗氧化剂测定法评估马郁兰茎和根的乙醇提取物的抗氧化活性。与抗坏血酸相比，茎和根的乙醇提取物在所有模型中均显示出强大的抗氧化活性，抗坏血酸的DPPH（2，2-diphenyl-picrylhydrazyl）的IC50值为21.05μgmL-1和84.98μgmL-1。用于H2O2自由基清除测定的492.8μgmL-1和477.6μgmL-1;分别用于金属螯合测定的156.9和141.79μgmL-1。与干乙醇提取物（0.527±0.14）相比，发现根乙醇提取物的还原能力高（吸光度0.747±0.23）。在植物的乙醇和水提取物（茎和根）上进行了体外黄嘌呤氧化酶抑制活性，发现两种乙醇提取物中的活性均具有IC50 59.21和148μgmL-1的显着性。研究了在大鼠中诱发的痛风的进一步体内抗痛风性。口服茎和根乙醇提取物（200和400 mg kg-1体重）显示，痛风大鼠的尿酸，肌酐，ESR（红细胞沉降率）和MDA（丙二醛）水平显着降低。减少的谷胱甘肽含量明显增加。没有发现蛋白质含量的变化。总之，所研究的植物提取物显示出与抗氧化和抗炎作用相关的显着变化的抗痛风活性，这可能是由于通过初步植物化学筛选显示出的类黄酮，酚类，皂苷和三萜类化合物的存在。

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