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首页> 外文期刊>American Journal of Drug Discovery and Development >Review on Enhancement of Solubilization Process
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Review on Enhancement of Solubilization Process

机译：增溶过程综述

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Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poorly water soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Water is the solvent of choice for liquid pharmaceutical formulations. Most of drugs are weakly acidic and weakly basic with poor aqueous solubility. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co-solvency, micellar solubilization, hydrotropy etc. The purpose of this review article is to describe the techniques of solubilizaton for the attainment of effective absorption and improved bioavailability.
机译：溶解度是固体在液相中溶解以形成均质体系的现象。溶解度是在全身循环中达到所需药物浓度以显示药理反应的重要参数之一。水溶性差的药物通常需要高剂量才能在口服后达到治疗性血浆浓度。低水溶性是新化学实体配方开发中遇到的主要问题。任何要吸收的药物必须以水溶液形式存在于吸收部位。水是液体药物制剂的首选溶剂。大多数药物为弱酸性和弱碱性，水溶性差。因此，用于改善水溶性差的药物的溶解度的各种技术包括微粉化，化学修饰，pH调节，固体分散，络合，共溶解，胶束增溶，亲水性等。本文的目的是描述用于实现有效吸收和提高生物利用度的增溶技术。

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