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首页> 外文期刊>American Journal of Drug Discovery and Development >In vitro Assessment of Novel Antimicrobial from Methanol Extracts of Matured Seed Kernel and Leaf of Mangifera indica L. (Kesar Mango) for Inhibition of Pseudomonas spp. and their Synergistic Potential
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In vitro Assessment of Novel Antimicrobial from Methanol Extracts of Matured Seed Kernel and Leaf of Mangifera indica L. (Kesar Mango) for Inhibition of Pseudomonas spp. and their Synergistic Potential

机译：芒果（Kesar Mango）成熟种子仁和叶片甲醇提取物中新型抗菌素的体外评估，用于抑制假单胞菌。及其协同潜能

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This study was done in order to determine the anti Pseudomonas potential of methanolic extracts and their fractions of matured seed kernel and leaf of Mangifera indica. The antibacterial susceptibility test was determined by agar well diffusion assay against five Pseudomonas spp. Thereafter, synergistic effect was determined by the minimal inhibitory concentration and the minimal bactericidal concentration using the micro broth dilution technique and synergistic effect was determined by calculating FIC index. Further, time kill assay was performed for the potential synergistic combination (ΣFICI≤0.1) at 1xMIC concentrations. The highest zone of inhibition was in crude extracts. The results of MIC and MBC showed potential anti Pseudomonas activity in the range of 9.75 to >250 and 156 to >1250 μg mL-1, respectively which was better than the standard drug used. Amongst all studied synergistic effects, RSM combined with LM showed better synergistic and bactericidal effects against P. syrigae. The results of this study indicate that it should be relatively easy to utilize antimicrobial extracts in future treatments for multi drug resistance strains.
机译：进行这项研究是为了确定印度extract的甲醇提取物及其成熟种子仁和叶片的级分的抗假单胞菌潜力。通过琼脂孔扩散测定法对五种假单胞菌属的菌种进行抗菌药敏试验。此后，使用微量肉汤稀释技术通过最小抑菌浓度和最小杀菌浓度确定协同效应，并通过计算FIC指数确定协同效应。此外，在1xMIC浓度下对潜在的协同组合（ΣFICI≤0.1）进行了时间杀灭测定。抑制的最高区域是粗提物中。 MIC和MBC的结果显示潜在的抗假单胞菌活性分别在9.75至> 250和156至> 1250μgmL-1的范围内，优于所用的标准药物。在所有研究的协同作用中，RSM与LM结合显示出对丁香假单胞菌更好的协同作用和杀菌作用。这项研究的结果表明，在未来对多药耐药菌株的治疗中使用抗菌提取物应该相对容易。

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