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首页> 外文期刊>American Journal of Drug Discovery and Development >Normalisation of Lipoprotein Phenotypes by Chromolaena odorata -Linn. in Carbon Tetrachloride Hepatotoxicity-Induced Dyslipidaemia
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Normalisation of Lipoprotein Phenotypes by Chromolaena odorata -Linn. in Carbon Tetrachloride Hepatotoxicity-Induced Dyslipidaemia

机译：变色衣原体-Linn对脂蛋白表型的归一化。四氯化碳肝毒性诱发的血脂异常

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The major functions of the liver can be detrimentally altered by liver injury resulting from acute or chronic exposure to toxicants. Dyslipidemia is often found in such toxicity resulting from chemical damage. Normalisation of atherogenic indices by Chromolaena odorata (C. odorata ) in carbon tetrachloride-induced liver toxicity was evaluated in 30 male rabbits divided into 5 groups of 6 animals each. Normal Control (NC) received food and water only. Carbon tetrachloride intoxicated control (CCl4) received a single dose of CCl4 (0.2 mL kgbw-1 in liquid paraffin 1:1). C. odorata test animals (ETECO TEST) received a single dose of CCl4 + ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1 morning and night, for 6 days. C. odorata control animals (ETECO CTRL) received ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1. Group five (Sylimarin) received sylimarin 50 mg/kgbw prior to CCl4 intoxication. Carbon tetrachloride-induced toxicity resulted in liver injury which was seen from the significant (p<0.05) elevation of the activities of serum Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Lactate Dehydrogenase (LDH) and gamma-Glutamyl Transferase (γ-GT), significantly decreased protein and albumin and significantly increased total bilirubin concentrations; altered lipid and lipoprotein phenotypes in favour of increased atherogenic indices. Pre-treatment with C. odorata extract prevented these biochemical alterations and normalized the lipoprotein phenotypes. C. odorata may be useful not only as a hepatoprotective agent, but also in the reduction and/or prevention of adverse cardiovascular events.
机译：急性或慢性暴露于有毒物质引起的肝损伤会损害肝脏的主要功能。血脂异常通常是由化学损伤引起的这种毒性所致。在四氯化碳诱导的肝毒性中，由香椿（Chromolaena odorata）（C. odorata）对致动脉粥样硬化指数的归一化进行了评估，将其分为30组，分为5组，每组6只动物。正常对照（NC）仅接收食物和水。四氯化碳中毒对照（CCl4）接受单剂量的CCl4（液体石蜡1：1中的0.2 mL kgbw-1）。香茅测试动物（ETECO TEST）以400 mg / kg /天的单剂量CCl4 +香茅乙醇提取物分两次服用，分为早，晚各200 mg kg-1，共6天。香兰假单胞菌对照动物（ETECO CTRL）以200 mg / kg-1的两个分剂量接受了400毫克/千克/天的香兰假单胞菌的乙醇提取物。第五组（Sylimarin）在CCl4中毒之前接受了50 mg / kgbw的sylimarin。从血清天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT），乳酸脱氢酶（LDH）和γ-谷氨酰转移酶（γ）的活性显着（p <0.05）升高可以看出，四氯化碳诱导的毒性导致了肝损伤。 -GT），蛋白质和白蛋白显着降低，总胆红素浓度显着升高;改变脂质和脂蛋白表型，以增加动脉粥样硬化指数。用香茅提取物进行预处理可防止这些生化改变并使脂蛋白表型正常化。香柠檬衣藻不仅可用作保肝剂，而且还可用于减少和/或预防不良心血管事件。

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