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首页> 外文期刊>American Journal of Drug Discovery and Development >pH Sensitive Drug Delivery Systems: A Review
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pH Sensitive Drug Delivery Systems: A Review

机译：pH敏感药物递送系统：综述

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pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. Diseases wherein PSDDS are promising include asthma, peptic ulcer, cardiovascular diseases, cancer and hypertension. The specific time that patients take their medication is very important as it has significant impact on treatment success. Optimal clinical outcome cannot be achieved if drug plasma concentrations are constant. If symptoms of a disease display circadian variation, drug release should also vary over time. Drug pharmacokinetics can also be pH-sensitive; therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose. PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form. These, as well as pertinent issues, are addressed in this review.
机译：pH敏感药物递送系统（PSDDS）变得越来越重要，因为这些系统根据疾病的病理生理需要在特定时间递送药物，从而提高了患者的治疗效率和依从性。 PSDDS很有前景的疾病包括哮喘，消化性溃疡，心血管疾病，癌症和高血压。患者服药的特定时间非常重要，因为它对治疗成功有重大影响。如果药物血浆浓度恒定，则无法获得最佳的临床结果。如果疾病症状显示昼夜节律变化，药物释放也应随时间变化。药物药代动力学也可以对pH敏感。因此，在开发旨在用于治疗具有足够剂量的疾病的药物输送系统时，必须考虑疾病状态和药物血浆浓度的变化。其中药物释放主要受递送系统控制的PSDDS，刺激诱导的PSDDS，其中释放受刺激（例如肠道中存在的pH）控制。这些系统对开发药物剂型过程中遇到的几个问题很有用。这些以及相关问题将在本次审查中解决。

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