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首页> 外文期刊>American Journal of Drug Discovery and Development >Evaluation of Bacterial Cellulose Produced Form Acetobacter xylinum as Pharmaceutical Excipient
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Evaluation of Bacterial Cellulose Produced Form Acetobacter xylinum as Pharmaceutical Excipient

机译：细菌纤维素产生的木醋杆菌作为药物赋形剂的评价

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Microcrystalline cellulose (Avicel 101, AV 101) has been widely used as the excipients for tablet formulation. The objective of this research was to produce cellulose from Acetobacter xylinum (A. xylinum) which is used as alternative excipient for tablet formulation instead of AV 101. The bacterium was isolated from kombucha tea preparation. Bacterial pellicle formation was cultivated in stationary conditions using a Herstin-Schramm nutrient (HS) medium. The produced Bacterial Cellulose (BC) was compared with AV 101 by carrying out Moisture Sorption Capacity (MSC), Loss on Drying (LOD), Scanning Electron Microscopy (SEM), FT-IR Spectroscopy, X-Ray diffraction analysis, micromeritic properties and compactibility studies. Comparisons revealed that MSC for AV 101 was higher when compared to BC due to crystalline nature of BC. LOD of BC was 4.635% which is required for good compression. The particles of BC were small sized densely packed reticulated structure consisting of fine thread like fibrils whereas AV 101 was irregularly large sized elongated structures. The IR spectra showed that there were no significant difference in the spectra of BC and AV 101. BC had higher crystallinity than AV 101. Micromeritic properties and compactibility studies showed that BC have high bulk density, better flow property, easy fragmentation of the particles and rearrangement at a lower compression load, lesser elastic recovery and higher tensile strength than AV 101. The result provides evidence that BC produced by HS medium can be suitably used as pharmaceutical excipient for tablet formulation instead of AV 101.
机译：微晶纤维素（Avicel 101，AV 101）已被广泛用作片剂制剂的赋形剂。这项研究的目的是从木醋杆菌（A. xylinum）生产纤维素，将其用作替代AV 101的片剂制剂的替代赋形剂。该细菌是从康普茶制剂中分离出来的。使用Herstin-Schramm营养（HS）培养基在静态条件下培养细菌菌丝形成。通过进行水分吸附能力（MSC），干燥失重（LOD），扫描电子显微镜（SEM），FT-IR光谱，X射线衍射分析，微粉体性质和压缩性研究。比较显示，由于BC的结晶特性，AV 101的MSC比BC高。 BC的LOD为4.635％，这是良好压缩所需的。 BC的颗粒是小尺寸的密集堆积的网状结构，由细丝状原纤维组成，而AV 101是不规则的大尺寸细长结构。红外光谱表明，BC和AV 101的光谱没有显着差异。BC比AV 101具有更高的结晶度。微团聚性质和可压实性研究表明BC具有高的堆积密度，更好的流动性，容易碎裂和分散。在比AV 101更低的压缩负荷，更少的弹性回复和更高的拉伸强度下进行了重排。结果提供了证据，证明HS介质产生的BC可以代替AV 101用作片剂的药用赋形剂。

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