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首页> 外文期刊>American Journal of Biochemistry >Pre- and Post-Treatment Effectiveness of SRP on Levels of IL-6, IL-10, and CRP in Chronic Periodontitis Patients with and without Diabetes
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Pre- and Post-Treatment Effectiveness of SRP on Levels of IL-6, IL-10, and CRP in Chronic Periodontitis Patients with and without Diabetes

机译：SRP对有或没有糖尿病的慢性牙周病患者治疗前后的IL-6，IL-10和CRP水平的影响

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Background : The relationship between periodontal disease and diabetes mellitus has been shown to be associated with activation of innate immunity. This is characterised by an altered inflammatory state in the diseased individuals. The present study assesses the effect of SRP (scaling and root planning) on some inflammatory markers in Chronic Periodontitis Patients with and without diabetes. Materials and Methods : A total of 168 individuals with generalized chronic periodontitis (CAL ≥ 3mm; American Association of Periodontology criteria 1999) were divided into two groups. Group I (CP): Non-diabetics (F Glucose≤ 5.5 mmol/L); n= 86; and Group II (CPDM): Diabetics (F Glucose≥ 7.0 mmol/L WHO 2006 criteria); n= 82. Their periodontal status was evaluated on the scale of gingival index (GI), plaque index (PI), probing depth (PD), and clinical attachment loss (CAL). The biochemical inflammatory markers assessed were Interleukins –6, –10, and C-Reactive Protein (CRP). The periodontal therapy (SRP) was performed on the individuals from both the groups and a follow-up was done after three months. Results : Individuals in the CPDM group showed significantly higher inflammation (p≤0.05) than those in the CP group. SRP reveals significant improvement (p≤0.001) in the study parameters compared to their corresponding pre-treatment values in both the groups. The extent of improvement, that is relative percentage change, also differed significantly (p≤0.05) between the groups. Conclusion : The patients with diabetes and periodontitis demonstrated higher oral and systemic inflammation compared to non-diabetics. The SRP therapy was effective in improving clinical and biochemical markers. However, the extent of improvement was lower in diabetic patients than those in the non-diabetic patients.
机译：背景：牙周疾病与糖尿病之间的关系已被证明与先天免疫的激活有关。其特征是患病个体的炎症状态改变。本研究评估了SRP（结垢和根部规划）对患有和不患有糖尿病的慢性牙周炎患者某些炎症指标的影响。 材料和方法：将168例患有广泛性慢性牙周炎（CAL≥3mm;美国牙周病协会标准1999）的患者分为两组。第一组（CP）：非糖尿病患者（F葡萄糖≤5.5 mmol / L）; n = 86;和第二组（CPDM）：糖尿病（F葡萄糖≥7.0mmol / L，WHO 2006标准）; n =82。根据牙龈指数（GI），牙菌斑指数（PI），探查深度（PD）和临床附着丧失（CAL）的量表评估他们的牙周状态。评估的生化炎症标志物是白介素–6，–10和C反应蛋白（CRP）。对两组患者进行牙周治疗（SRP），三个月后进行随访。 结果：CPDM组的个体发炎（p≤0.05）明显高于CP组。与两组中相应的预处理值相比，SRP显示研究参数有显着改善（p≤0.001）。各组之间的改善程度（即相对百分比变化）也存在显着差异（p≤0.05）。 结论：与非糖尿病患者相比，糖尿病和牙周炎患者表现出更高的口腔和全身炎症。 SRP治疗有效改善了临床和生化指标。但是，糖尿病患者的改善程度低于非糖尿病患者。

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