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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Gibberellin-regulated protein allergy: Clinical features and cross-reactivity
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Gibberellin-regulated protein allergy: Clinical features and cross-reactivity

机译：赤霉素调节的蛋白质过敏：临床特征和交叉反应

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Gibberellin-regulated proteins (GRPs)/GASA proteins are members of cysteine-rich antimicrobial peptide families and are conserved in a broad range of plants. Some GRPs in fruits and pollens have been identified as allergens including peach Pru p 7, Japanese apricot Pru m 7, orange Cit s 7, pomegranate Pun g 7, and cypress pollen GRP. The clinical features of fruit-derived GRP allergies frequently include systemic reactions, multiple fruit allergies regardless of plant kingdom classifications and, less frequently, cofactor-dependence. Multiple fruit allergies might be related to cross-reactivity between GRPs. Clinical cross-reactivity, at least between the four fruit-derived GRPs, has been proven. In addition, GRP allergy induces peculiar clinical symptoms, such as laryngeal tightness and facial swelling, especially eyelid edema, which was proposed to be a predictive factor for Pru p 7 allergy. Fruit-derived GRPs have an unusually high content of cysteine, resulting in high stability to heat and resistance to digestive enzymes. Therefore, GRPs are considered “true” food allergens that induce severe allergic reactions. As an alternative mechanism of fruit-derived GRP allergies, cross-reactivity between fruit GRP and cypress pollen GRP, which might play a role as a sensitizer, is suspected. Taken together, these characteristics indicate GRPs are clinically relevant plant allergens.This review article summarizes our current knowledge of the clinical features and important aspects of GRP sensitization and allergy.
机译：赤霉素调节蛋白（GRPs）/ GASA蛋白是富含半胱氨酸的抗菌肽家族的成员，在许多植物中均得到保守。水果和花粉中的某些GRP已被鉴定为过敏原，包括桃Pru p 7，日本杏Pru m 7，橙Cit s 7，石榴Pun g 7和柏树花粉GRP。源自水果的GRP过敏的临床特征通常包括全身反应，与植物界分类无关的多种水果过敏，以及不常见的辅因子依赖性。多种水果过敏可能与GRP之间的交叉反应性有关。临床交叉反应性，至少在四个水果衍生的GRP之间已得到证明。此外，GRP过敏会诱发特殊的临床症状，例如喉头紧绷和面部肿胀，尤其是眼睑浮肿，这被认为是Pru p 7过敏的预测因素。源自水果的GRP具有异常高的半胱氨酸含量，从而具有很高的耐热稳定性和对消化酶的抵抗力。因此，GRP被认为是诱发严重过敏反应的“真实”食物过敏原。怀疑是水果衍生的GRP过敏的另一种机制，怀疑是水果GRP和柏树花粉GRP之间的交叉反应性，可能起敏化作用。综上所述，这些特征表明GRP是与临床相关的植物过敏原。本文综述了我们目前对GRP致敏和过敏的临床特征以及重要方面的认识。

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