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首页> 外文期刊>American Journal of Cancer Prevention >Clinicopathology Figures of Breast Cancer Women with Brain Metastasis and Invasive Ductal Carcinoma
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Clinicopathology Figures of Breast Cancer Women with Brain Metastasis and Invasive Ductal Carcinoma

机译：患有脑转移和浸润性导管癌的乳腺癌妇女的临床病理学数字

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Background: Breast cancer (BC) metastasis to the central nervous system (CNS) or brain metastases include the clinically distinct situations of multiple brain metastasis (78%), solitary brain metastasis (14%), and leptomeningeal metastasis (8%). The aim of this study is to describe clinicopathologic features of patients with BC brain metastasis and to compare estrogen receptor (ER), progesterone receptor (PR), and Her2 expression in them. Materials and Methods: there were 16 patients with brain metastasis and we entered them to our study. Age, sex, kind of pathology, tumor markers, type of treatment, histological grade, size of tumor, laterality and other metastasizes were checked for the patients. ER and PR positivity was defined as ≥10% positive tumor cells with nuclear staining. HER2 positivity was defined as either HER2 gene amplification by fluorescent in situ hybridization or scored as 3+ by IHC. Results: The mean age at diagnosis for the patients was 42.2 years (±14.4) and range of 27 to 73 years that 100% were female. ER, PR, Her-2 and p53 positive for the patients were 43.7%, 56.3%, 43.7% and 37.5%, respectively. Three patients (18.7%) had grade I, nine patients (56.3%) had grade II and four patients (25%) had grade III. The mean OS was 24.7 months with survival rate of 50%. Lymph node metastasis for 13 patients (81.2%) was positive. Conclusions: The mean age for patients with brain metastatic BC at diagnosis is more between 45 to 52 years and also brain metastasis in BC occurs more in HER-2-overexpressing and TNBC. Size of tumor in BC patients >5 cm is a prognostic factor for brain metastasis.
机译：背景：乳腺癌（BC）转移到中枢神经系统（CNS）或脑转移包括临床上不同的情况，包括多脑转移（78％），孤立性脑转移（14％）和软脑膜转移（8％）。这项研究的目的是描述患有BC脑转移的患者的临床病理特征，并比较其中的雌激素受体（ER），孕激素受体（PR）和Her2表达。材料和方法：共有16例脑转移患者，我们将其纳入研究。检查患者的年龄，性别，病理学类型，肿瘤标志物，治疗类型，组织学等级，肿瘤大小，偏侧性和其他转移灶。 ER和PR阳性定义为≥10％带有核染色的阳性肿瘤细胞。 HER2阳性定义为通过荧光原位杂交扩增HER2基因或通过IHC评分为3+。结果：患者的平均诊断年龄为42.2岁（±14.4），范围为27至73岁，其中100％为女性。患者的ER，PR，Her-2和p53阳性分别为43.7％，56.3％，43.7％和37.5％。 I级为三例（18.7％），II级为九例（56.3％），III级为四例（25％）。平均OS为24.7个月，生存率为50％。 13例患者的淋巴结转移（81.2％）为阳性。结论：诊断为脑转移性BC的患者的平均年龄在45至52岁之间，并且在HER-2过表达和TNBC中，发生于BC的脑转移的发生率更高。 BC患者> 5 cm的肿瘤大小是脑转移的预后因素。

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