Amyloid Cardiomyopathy in African Americans and the Transthyretin Linkage Associated with Macroglossia: A Rare Presentation

Roberto Ramirez; Glenmore Lasam; Gina LaCapra

首页> 外文期刊>American Journal of Cardiovascular Disease Research >Amyloid Cardiomyopathy in African Americans and the Transthyretin Linkage Associated with Macroglossia: A Rare Presentation

【24h】

Amyloid Cardiomyopathy in African Americans and the Transthyretin Linkage Associated with Macroglossia: A Rare Presentation

机译：非裔美国人的淀粉样变性心肌病和甲状腺功能亢进症相关的运甲状腺素蛋白联结：罕见的表现。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We report a case of a 63 year old African American female with congestive heart failure, poorly controlled hypertension, and end stage renal disease admitted for STEMI (ST Elevation Myocardial Infarction) and hypertensive crisis. Macroglossia was noticed during hospitalization and an echocardiogram was suggestive of cardiac infiltrative disease. Protein electrophoresis and immunofixation were negative. Although macroglossia is a common finding in light chain (AL) amyloidosis, there are reported cases in transthyretin (ATTR) amyloidosis. Learning objective: To highlight a rare presentation of transthyretin amyloidosis, and to raise awareness of this disease and its particular prevalence in the African American and African Caribbean populations.

机译：我们报告了一例63岁的非洲裔美国女性，患有充血性心力衰竭，高血压控制不佳以及因STEMI（ST抬高型心肌梗塞）和高血压危疾而入院的终末期肾脏疾病。住院期间发现巨眼症，超声心动图提示心脏浸润性疾病。蛋白质电泳和免疫固定均为阴性。尽管大舌症是轻链（AL）淀粉样变性的常见发现，但有报道称运甲状腺素蛋白（ATTR）淀粉样变性。学习目标：突出转甲状腺素蛋白淀粉样变性的罕见表现，并提高对这种疾病及其在非裔美国人和非洲加勒比海人群中特别流行的认识。

著录项

来源
《American Journal of Cardiovascular Disease Research》 |2016年第2期|共4页
作者
Roberto Ramirez; Glenmore Lasam; Gina LaCapra;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类心脏、血管（循环系）疾病;
关键词
amyloidosisAfrican-Americanafrican-caribbeantransthyretin amyloidosismacroglossiacongestive heart failure;

机译：非裔美国人-非洲-非洲-加勒比运甲状腺素蛋白淀粉样变性病Macroglossia充血性心力衰竭;

相似文献

外文文献
中文文献
专利

1. A transthyretin variant, Asp18Asn, associated with amyloid cardiomyopathy: A new African-American variant [J] . QuartaC.C., FalkR.H. Amyloid: the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis . 2012,第4期

机译：转甲状腺素蛋白变体Asp18Asn与淀粉样心肌病有关：一种新的非裔美国人变体
2. Amyloid Cardiomyopathy in the Rare Transthyretin Tyr78Phe Mutation [J] . Tini Giacomo, Vianello Pier Filippo, Gemelli Chiara, Journal of cardiovascular translational research . 2019,第6期

机译：在罕见的Transthyretin tyr78phe突变中的淀粉样蛋白心肌病
3. Transthyretin V122I ( pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans [J] . Buxbaum Joel N., Ruberg Frederick L. Genetics in medicine . 2017,第7期

机译：Transthyretin v122i（pv142i）*心脏淀粉样症：年龄依赖性常染色体显性心肌病过于常见，不能被忽视为老年非洲裔美国人的重要心脏病
4. INCIDENCE OF TRANSTHYRETIN VAL122ILE AMYLOID MUTATION IN AFRICAN-AMERICANS BORN IN INDIANAPOLIS, INDIANA, USA [C] . M.D. Benson, M. Yazaki, T. Yamashita, International Symposium on Amyloidosis . 2005

机译：在美国印第安纳州印第安纳波利斯出生的非裔美国人的Transthyretin Val122ile淀粉样蛋白突变的发病率
5. The Competing Physiological Roles of Transthyretin and Mechanistic Insight into Transthyretin-Mediated Inhibition of Beta-Amyloid Aggregation [D] . Mangrolia, Parth Vinod. 2018

机译：运甲状腺素蛋白的竞争性生理作用和对运甲状腺素蛋白介导的β-淀粉样蛋白聚集抑制的机理研究。
6. Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans [O] . Joel N. Buxbaum, Frederick L. Ruberg -1

机译：运甲状腺素蛋白V122I（pV142I）*心脏淀粉样变性：一种年龄依赖性常染色体显性心肌病太常见了不被认为是导致老年非洲裔美国人严重心脏病的原因
7. Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans [O] . Joel N. Buxbaum, Frederick L. Ruberg 2017

机译：transthyretin v122i（pv142i）*心脏淀粉样蛋白症：年龄依赖性常规的常染色体显性心肌病过于常见，被忽视为老年非洲裔美国人的重要心脏病

Amyloid Cardiomyopathy in African Americans and the Transthyretin Linkage Associated with Macroglossia: A Rare Presentation

摘要

著录项

相似文献

相关主题

期刊订阅