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首页> 外文期刊>American Journal of Cardiovascular Disease Research >The Metabolic Syndrome in Offspring of Women with a Family History of Early Onset Type 2 Diabetes Mellitus Who Developed Gestational Diabetes Mellitus
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The Metabolic Syndrome in Offspring of Women with a Family History of Early Onset Type 2 Diabetes Mellitus Who Developed Gestational Diabetes Mellitus

机译：具有早期妊娠2型糖尿病家族史并发展妊娠糖尿病的女性后代的代谢综合症

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Objective: To evaluate for the metabolic syndrome (MS) in offspring of women with family history of early onset type 2 diabetes mellitus (T2DM) who developed gestational diabetes mellitus (GDM) using as controls offspring of women with no family history of diabetes and normal glucose tolerance (NGT). Methods: Anthropometric and biochemical measurements were evaluated for 30 offspring age 10-16 years of women with family history of early onset T2DM who developed GDM. Obstetrical records of these mothers were also noted. Thirty offspring of women (30) with NGT and no family history of diabetes served as controls. Measurements included: Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting and postprandial glucose, insulin, waist circumference, weight and height. For analyses, MS was defined as ≥3 of 4 features: glucose intolerance, dyslipidemia, obesity and hypertension in the childhood/adolescence criteria as recommended by the National Cholesterol Education Program Adult Treatment Panel Third (NCEP-ATP III) modified standard. Cox regression analysis was used to determine the independent hazard (risk) of developing MS attributable to GDM with a family history of early onset T2DM. Results: Offspring of women with GDM and family history of early onset T2DM had significantly more (≥ 2, p<0.05) features of MS than offspring of women with NGT and no family history of diabetes. Thirty percent (30.0%), 29.5% and 39.0% of the offspring of these GDM women had glucose intolerance, obesity and dyslipidemia respectively. These offspring had a hazard of 3.33 (95% CI: 2.12-9.15) of having MS compared to offspring of women with NGT and no family history of diabetes. Conclusion: Offspring of women with GDM and family history of early onset T2DM are at increased risk for MS.
机译：目的：以无糖尿病家族史且正常的女性作为后代，评估具有妊娠糖尿病（GDM）的早发2型糖尿病（T2DM）家族史的女性后代的代谢综合征（MS）。葡萄糖耐量（NGT）。方法：对30例年龄在10-16岁的患有早发性T2DM家族史并发展为GDM的妇女的后代进行人体测量和生化测量。还记录了这些母亲的产科记录。 30例患有NGT且无糖尿病家族史的妇女（30例）作为对照。测量包括：总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），甘油三酸酯（TG），空腹和餐后葡萄糖，胰岛素，腰围，体重和身高。为了进行分析，按照国家胆固醇教育计划成人治疗小组第三次修订标准（NCEP-ATP III）的建议，将MS定义为≥4个特征中的3个：葡萄糖耐受不良，血脂异常，肥胖和高血压。使用Cox回归分析来确定可归因于GDM的发展中MS的独立危险（风险），该家族病具有早期T2DM的家族史。结果：具有GDM和早发型T2DM家族史的女性的子代比具有NGT和无糖尿病家族史的女性的子代具有更多的MS特征（≥2，p <0.05）。这些GDM妇女的后代中有30％（30.0％），29.5％和39.0％分别患有葡萄糖耐受不良，肥胖和血脂异常。与具有NGT但没有糖尿病家族史的女性的后代相比，这些后代患MS的危险为3.33（95％CI：2.12-9.15）。结论：患有GDM的女性的后代和早发T2DM的家族病史患MS的风险增加。

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