• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Drug Discovery and Development >Comparative Antimalarial and Safety Attributes of Methanolic Extract of Leaves of Tithonia diversifolia and Morinda lucida in Animal Models
【24h】

Comparative Antimalarial and Safety Attributes of Methanolic Extract of Leaves of Tithonia diversifolia and Morinda lucida in Animal Models

机译：Tithonia diversifolia和Morinda lucida叶片甲醇提取物在动物模型中的比较抗疟和安全性。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Anti-malarial property and toxicity of methanolic extract of leaves of Tithonia diversifolia and Morinda lucida were investigated in mice and rats, respectively. Percentage parasitemia and chemosuppresive effect of the extract on Plasmodium berghei infected mice were used to assess anti-malarial property while toxicity was evaluated by measuring the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and some selected tissues as well as evaluation of some hematological parameters, serum electrolytes, urea and creatinine in rats. The extract at 200 mg kg-1 b.wt. showed significant (p<0.05) chemo suppressive effect following five days administration in P. berghei established infection. There was a significant decrease (p<0.05) in the liver, kidney and serum activities of ALT following 7 and 14 days administration of the extract. Similar trends were observed in liver and serum ALP and liver AST. However, there was a significant increase (p<0.05) in kidney and serum AST activity for both periods of administration except for the significant decrease (p<0.05) in the kidney following the 14 days administration. The white blood counts showed a significant decrease (p<0.05) following administration of T. diversifolia for 7 and 14 days and M. lucida for 14 days while administration of both extract for 14 days revealed a significant increase (p<0.05) in platelet counts. Serum bicarbonate, chloride, sodium, potassium and urea decreased significantly (p<0.05) following administration of the extract for 7 and 14 days. This result therefore suggests that, methanolic extract of T. diversifolia and M. lucida possess considerable anti-malarial property but may potentiate some level of toxicity especially if administration is prolonged.
机译：分别在小鼠和大鼠中研究了虎杖和巴戟天叶片的甲醇提取物的抗疟性能和毒性。提取物对柏氏疟原虫感染小鼠的寄生虫百分率和化学抑制作用用于评估抗疟疾特性，同时通过测量血清中碱性磷酸酶（ALP），丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的活性来评估毒性。大鼠的一些选定组织以及一些血液学参数，血清电解质，尿素和肌酐的评估。提取物为200 mg kg-1 b.wt.在伯氏疟原虫确定的感染中施用五天后显示出显着（p <0.05）的化学抑制作用。服用提取物7和14天后，ALT的肝，肾和血清活性显着降低（p <0.05）。在肝脏，血清ALP和肝脏AST中也观察到类似趋势。但是，除了14天给药后肾脏的显着下降（p <0.05）外，两个给药阶段的肾脏和血清AST活性均显着增加（p <0.05）。给予T. diversifolia 7天和14天，以及M. lucida给予14天后，白血球计数显着下降（p <0.05），而给予两种提取物14天都显示出血小板的显着增加（p <0.05）计数。给予提取物7天和14天后，血清碳酸氢盐，氯化物，钠，钾和尿素显着降低（p <0.05）。因此，该结果表明，T。diversifolia和M. lucida的甲醇提取物具有显着的抗疟疾特性，但可能增强一定程度的毒性，特别是如果延长给药时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号