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首页> 外文期刊>American Journal of Psychiatry and Neuroscience >Evaluation of Nootropic Activity of Persicaria flaccida on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer's Disease
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Evaluation of Nootropic Activity of Persicaria flaccida on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer's Disease

机译：评价Persicaria flaccida的促智活性对大鼠认知能力，脑抗氧化剂和乙酰胆碱酯酶活性的影响：对阿尔茨海默氏病的管理意义

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Oxidative stress is the leading cause of neurodegenerative diseases, especially Alzheimer's disease (AD). The plant Persicaria flaccida (PF) is known in Bengali as red Biskatali belongs to family Polygonaceae. Preliminary studies have shown the antioxidant, anti-inflammatory, analgesic, neuroprotective activities of Biskatali. In this consequence, methanolic extract of PF (MEPF) was selected to explore the ability of this plant to enhance cognitive functions, brain antioxidant enzymes and anti-acetylcholinesterase activity which can be used for the treatment of AD. The objective of this study was to investigate the effects of MEPF on cognitive performance, brain antioxidant enzymes and acetylcholinesterase activity in rats by using behavioral and biochemical study. Treatment with MEPF (i.e., 100 and 200 mg/kg b.w.) was investigated for 14 days in Swiss albino male rats and its effects on different types of memory were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GSR), glutathione-S-transferase (GST) and contents of thiobarbituric acid reactive substances (TBARS) in rat brain tissue homogenates. Acetylcholinesterase (AChE) activity was determined by colorimetric method. Administration of highest dose of MEPF significantly (P < 0.05, P < 0.01) decreased retention transfer latency (RTL) of rats on 7th and 14th day compared to the control group in EPM test. In PA test highest dose of MEPF meaningfully (P < 0.05, P < 0.01) increased step-through latency (STL) of rats on 7th, 12th, 13th and 14th day with respect to control group. Both doses of MEPF markedly (P < 0.01, P < 0.001) decreased escape latency (EL), increased time spent in the target quadrant (TSTQ) and time spent in the annuli (TSA) of rats on successive days as compared to that of control group in MWM test. MEPF administration, especially highest dose significantly (P < 0.05, P < 0.01, P < 0.001) increased the level of CAT, SOD, GSR, GST & GSH-Px and considerably (P < 0.01, P < 0.001) decreased TBARS level & AChE activity in the brain tissue homogenates of rats compared to the control group. Behavioral and biochemical studies suggest that MEPF promotes cognitive function by improving different types of memory and reduces oxidative stress by increasing the level of brain antioxidant markers and anti-acetylcholinesterase activity. Therefore, this plant extract can be used for enhancing memory in neurodegenerative disorders like AD.
机译：氧化应激是神经退行性疾病，尤其是阿尔茨海默氏病（AD）的主要原因。孟加拉桃（Persicaria flaccida）（PF）植物在孟加拉国被称为红色Biskatali，属于Poly科。初步研究表明，比斯卡达利具有抗氧化，消炎，镇痛和神经保护作用。因此，选择了PF的甲醇提取物（MEPF）来探索该植物增强可用于治疗AD的认知功能，脑部抗氧化酶和抗乙酰胆碱酯酶活性的能力。这项研究的目的是通过行为和生化研究来研究MEPF对大鼠认知能力，大脑抗氧化酶和乙酰​​胆碱酯酶活性的影响。在瑞士的白化病雄性大鼠中研究了MEPF（即100和200 mg / kg bw）的治疗14天，并使用高架迷宫（EPM）测试，被动回避（PA）测试检查了其对不同类型记忆的影响， Morris水迷宫（MWM）测试以及抗氧化酶的水平，例如过氧化氢酶（CAT），超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH-Px），谷胱甘肽还原酶（GSR），谷胱甘肽S-转移酶（GST）和大鼠脑组织匀浆中硫代巴比妥酸反应性物质（TBARS）的含量。用比色法测定乙酰胆碱酯酶（AChE）的活性。与EPM测试中的对照组相比，给予最高剂量的MEPF（P <0.05，P <0.01）可以显着降低大鼠在第7天和第14天的保留转移潜伏期（RTL）。在PA测试中，相对于对照组，最高剂量的MEPF（P <0.05，P <0.01）显着增加了大鼠在第7、12、13和14天的逐步通过潜伏期（STL）。两种剂量的MEPF（P <0.01，P <0.001）均显着降低了逃避潜伏期（EL），在目标象限（TSTQ）中花费的时间和在大鼠环上（TSA）中花费的时间（与连续时间相比）对照组进行MWM测试。 MEPF给药，尤其是最高剂量显着（P <0.05，P <0.01，P <0.001）增加CAT，SOD，GSR，GST和GSH-Px的水平，而显着（P <0.01，P <0.001）降低TBARS水平，与对照组相比，大鼠脑组织匀浆中的AChE活性。行为和生化研究表明，MEPF通过改善不同类型的记忆来促进认知功能，并通过增加大脑抗氧化剂和抗乙酰胆碱酯酶的水平来降低氧化应激。因此，该植物提取物可用于增强神经退行性疾病如AD的记忆。

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