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首页> 外文期刊>American Journal of Psychiatry and Neuroscience >Laryngeal Dystonia, New Approaches for Direct Botulinum Toxin Administration
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Laryngeal Dystonia, New Approaches for Direct Botulinum Toxin Administration

机译：喉肌张力障碍，直接肉毒杆菌毒素管理的新方法

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To describe our experience in the treatment of laryngeal dystonia (in abduction and adduction), with special emphasis given to the technical aspects (approach procedure, dosage and type of botulinum toxin type A used), as well as treatment response and possible side effects. We conducted a cross-sectional descriptive study of a sample of patients with laryngeal dystonia treated by means of transoral administration of onabotulinumtoxinA or incobotulinumtoxinA over a period of 10 years (2007-2017). Data collected include demographic and clinical variables, treatment response (based on a self-rating scale), the duration of treatment and the appearance of side effects. Sample size: 15 patients (11 women; mean age: 44.06 years) with laryngeal dystonia (mean time since onset of 40 months; 12 patients with dystonia in adduction) and 174 administrations (92% incobotulinumtoxinA; average dosage of 5 U in each vocal cord). The procedure took an average of 11.7 minutes to perform. Response was good in 31% of the procedures and very good in 57.5%. Side effects were recorded in 14.4% of the procedures, although always mild and transitory, with a predominance of dysphagia and dysphonia. In our experience, transoral administration of botulinum toxin type A to treat laryngeal dystonia has proved to be a simple, quick, effective and safe technique.
机译：描述我们在治疗咽喉肌张力障碍（外展和内收）方面的经验，并特别强调技术方面（方法，使用的A型肉毒毒素的剂量和类型）以及治疗反应和可能的副作用。我们进行了横断面描述性研究，对10年来（2007-2017年）经经口施用onabotulinumtoxinA或incobotulinumtoxinA治疗的喉肌张力障碍患者的样本进行了横断面描述研究。收集的数据包括人口统计学和临床​​变量，治疗反应（基于自评量表），治疗持续时间和副作用的出现。样本量：15例（11例女性;平均年龄：44.06岁）患有咽喉肌张力障碍（平均发病时间为40个月;内收肌张力障碍患者12例）和174次给药（92％肌肉蛋白毒素A;每声带平均5 U）线）。该过程平均花费11.7分钟执行。 31％的手术反应良好，而57.5％的反应良好。在该手术中，有14.4％的人记录到了副作用，尽管总是轻度和短暂的，主要表现为吞咽困难和声音障碍。根据我们的经验，经口施用A型肉毒杆菌毒素已被证明是一种简单，快速，有效和安全的技术，可治疗喉肌张力障碍。

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