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首页> 外文期刊>Allergy, Asthma & Clinical Immunology >The effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis
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The effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis

机译：多种变应原免疫疗法对成人变应性鼻炎呼出气一氧化氮的影响

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Background There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients’ perception about the effect of this treatment. We studied whether the fraction of exhaled nitric oxide is affected by multiple allergen immunotherapy in polysensitized adult subjects with allergic rhinitis. We also looked for associations between exhaled nitric oxide and subjects’ demographics, symptom scores, and pulmonary function tests. Methods Twenty adult, polysensitized subjects with seasonal and perennial allergic rhinitis who chose to undergo allergen immunotherapy were enrolled. They were evaluated at baseline, and 4, 8, 12, 24, and 52?weeks later. Exhaled nitric oxide was reported as the mean of triplicate determinations. Findings Our results indicate that multiple allergen immunotherapy did not affect exhaled nitric oxide levels and such levels did not correlate with subjects’ demographics and pulmonary function tests. However, exhaled nitric oxide was associated with rhinoconjuctivitis and asthma symptom scores at the end of the study. Conclusions In polysensitized adult subjects with allergic rhinitis, exhaled nitric oxide levels are unaffected by multiple allergen immunotherapy.
机译：背景技术缺乏客观的方法来衡量过敏原免疫疗法的临床疗效，这取决于患者对这种疗法效果的看法。我们研究了过敏性鼻炎的多敏感成人受试者中，呼出气一氧化氮的分数是否受到多重过敏原免疫疗法的影响。我们还寻找呼出气一氧化氮与受试者的人口统计学，症状评分和肺功能检查之间的关联。方法招募了二十名选择进行过敏原免疫治疗的成年多发性季节性和常年性过敏性鼻炎患者。他们在基线以及第4、8、12、24和52周后进行了评估。据报告，呼出的一氧化氮为一式三份测定的平均值。研究结果我们的结果表明，多种变应原免疫疗法不会影响呼出气中一氧化氮的水平，并且这种水平与受试者的人口统计学和肺功能测试没有关联。然而，在研究结束时，呼出的一氧化氮与鼻结膜炎和哮喘症状评分有关。结论在多发性过敏性鼻炎的成人受试者中，呼出气中的一氧化氮水平不受多种过敏原免疫疗法的影响。

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