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首页> 外文期刊>Advances in Nephrology >Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome
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Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome

机译：Rho-GTPase信号转导在肾病综合征的发病机制中。

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Nephrotic syndrome (NS) is characterized by heavy proteinuria, hypoalbuminemia, and edema. The underlying causes of NS are diverse and are tied to inheritable and environmental factors. A common diagnostic marker for NS is effacement of podocyte foot processes. The formation and maintenance of foot processes are under the control of many signalling molecules including Rho-GTPases. Our knowledge of Rho-GTPases is based largely on the functions of three prototypic members: RhoA, Rac1, and Cdc42. In the event of podocyte injury, the rearrangement to the actin cytoskeleton is orchestrated largely by this family of proteins. The importance of maintaining proper actin dynamics in podocytes has led to much investigation as to how Rho-GTPases and their regulatory molecules form and maintain foot processes as a critical component of the kidney’s filtration barrier. Modern sequencing techniques have allowed for the identification of novel disease causing mutations in genes such asARHGDIA, encoding Rho-GDIα. Continued use of whole exome sequencing has the potential to lead to the identification of new mutations in genes encoding Rho-GTPases or their regulatory proteins. Expanding our knowledge of the dynamic regulation of the actin network by Rho-GTPases in podocytes will pave the way for effective therapeutic options for NS patients.
机译：肾病综合征（NS）的特点是蛋白尿过多，白蛋白血症和水肿。 NS的根本原因是多种多样的，并且与可遗传和环境因素有关。 NS的常见诊断标志是足细胞足突的消失。足突的形成和维持受包括Rho-GTP酶在内的许多信号分子的控制。我们对Rho-GTPase的了解主要基于三个原型成员的功能：RhoA，Rac1和Cdc42。在足细胞损伤的情况下，肌动蛋白细胞骨架的重排很大程度上由该蛋白家族来安排。在足细胞中维持适当的肌动蛋白动态的重要性已导致大量研究，涉及Rho-GTPases及其调节分子如何形成并维持足部进程，这是肾脏滤过屏障的重要组成部分。现代测序技术已允许鉴定导致编码Rho-GDIα的基因如ARHGDIA突变的新型疾病。继续使用整个外显子组测序有可能导致鉴定编码Rho-GTPases或其调节蛋白的基因中的新突变。扩大我们对Rho-GTPases在足细胞中对肌动蛋白网络动态调节的认识，将为NS患者的有效治疗选择铺平道路。

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