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首页> 外文期刊>ACS Central Science >Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications
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Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications

机译：具有高鲁棒性，可量化的表面增强拉曼散射信号的脱胶纳米颗粒内颗粒，用于生物传感和生物成像应用

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摘要

Uniformly controlling a large number of metal nanostructures with a plasmonically enhanced signal to generate quantitative optical signals and the widespread use of these structures for surface-enhanced Raman scattering (SERS)-based biosensing and bioimaging applications are of paramount importance but are extremely challenging. Here, we report a highly controllable, facile selective-interdiffusive dealloying chemistry for synthesizing the dealloyed intra-nanogap particles (DIPs) with a ～2 nm intragap in a high yield (～95%) without the need for an interlayer. The SERS signals from DIPs are highly quantitative and polarization-independent with polarized laser sources. Remarkably, all the analyzed particles displayed the SERS enhancement factors (EFs) of ≥1.1 × 108 with a very narrow distribution of EFs. Finally, we show that DIPs can be used as ultrasensitive SERS-based DNA detection probes for detecting 10 aM to 1 pM target concentrations and highly robust, quantitative real-time cell imaging probes for long-term imaging with low laser power and short exposure time.
机译：用等离激元增强的信号均匀地控制大量金属纳米结构以产生定量的光信号，并且这些结构在基于表面增强拉曼散射（SERS）的生物传感和生物成像应用中的广泛应用极为重要，但极具挑战性。在这里，我们报道了一种高度可控的，易于选择的-相互扩散的脱合金化学方法，用于以约2nm的内间隙以高收率（〜95％）合成脱合金的纳米间隙内颗粒（DIP），而无需中间层。来自DIP的SERS信号是高度定量的，并且与偏振激光源偏振无关。值得注意的是，所有分析过的颗粒均显示SERS增强因子（EFs）≥1.1×108，且EFs分布非常窄。最后，我们证明DIP可用作基于超敏感SERS的DNA检测探针，可检测10 aM到1 pM的目标浓度，以及高度耐用的定量实时细胞成像探针，可用于低激光功率和短曝光时间的长期成像。

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