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首页> 外文期刊>Aging cell. >Paternal age and telomere length in twins: the germ stem cell selection paradigm
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Paternal age and telomere length in twins: the germ stem cell selection paradigm

机译：双胞胎的父亲年龄和端粒长度：生殖干细胞选择范例

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SummaryTelomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an ‘epigenetic’ mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.
机译：总结：长尾猴的端粒长度较长，在年长的父亲的后代中较长。这种令人困惑的特征归因于老年男性精子中端粒更长，这可能是“表观遗传”机制，父本年龄通过这种机制在人类端粒长度调节中发挥作用。基于两个独立的（发现和复制）双胞胎研究，包括889对双胞胎，我们显示年长父亲的同卵双胞胎之间白细胞端粒长度的相似性增加，这在同卵双胞胎中未见。这种现象可能是由父系年龄相关的生殖干细胞选择过程引起的，其中所选的干细胞具有更长的端粒，端粒长度更均一，并具有抗衰老的能力。

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