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首页> 外文期刊>American Journal of Epidemiology and Infectious Disease >Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens
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Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

机译：某些非甾体类抗炎药和N-乙酰半胱氨酸对某些生物膜产生性致病菌的抗菌，抗生物膜活性

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摘要

Ureteral catheters are indispensable devices used in the management of ureteral obstruction. Although the stent is essential for treatment, it also has complications, which are encrustation, stone formation and biofilm formation. Biofilm infections result in a complication in the course of treatment, increasing the length of patients stay in hospital and overall cost. Catheter-associated infections are difficult to be treated with antibiotics and there is a need to change catheters due to the formation of biofilm on their surfaces. In this study, In this study, we examine the effect of some of prescribed drugs as NSAIDs and N-acetylcysteine on the adherence of S. aureus, K. pneumoniae, P. aeruginosa and Proteus mirabilis on the surface of catheters, and their effects on the preformed mature biofims. Also, we determine their antibacterial activity. The results showed that the tested agents had good antibacterial activity, a significant effect on the inhibition of adherence of the tested strains to plastic surfaces and a high disruptive effect on mature biofilms. In conclusion, the tested drugs can be used in the treatment of catheter-associated infections.
机译：输尿管导管是用于管理输尿管阻塞的必不可少的设备。尽管支架对于治疗必不可少，但它也具有并发症，例如结壳，结石和生物膜形成。生物膜感染会导致治疗过程中的并发症，增加患者住院时间和总体费用。与导管相关的感染很难用抗生素治疗，并且由于其表面上形成生物膜而需要更换导管。在这项研究中，我们研究了某些处方药（如NSAIDs和N-乙酰半胱氨酸）对金黄色葡萄球菌，肺炎克雷伯菌，铜绿假单胞菌和奇异变形杆菌在导管表面粘附的影响，以及它们的作用在预先形成的成熟生物膜上。另外，我们确定它们的抗菌活性。结果表明，所测试的试剂具有良好的抗菌活性，对所测试菌株对塑料表面的粘附的抑制作用显着，对成熟生物膜的破坏力也很高。总之，被测药物可用于治疗导管相关感染。

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