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首页> 外文期刊>American Journal of Epidemiology and Infectious Disease >Molecular Epidemiology of Adenovirus Strains Genotypes among Patients with Acute Follicular Conjunctivitis
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Molecular Epidemiology of Adenovirus Strains Genotypes among Patients with Acute Follicular Conjunctivitis

机译：急性滤泡性结膜炎患者腺病毒株基因型的分子流行病学

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Background: Adenoviruses are a group of viruses that can infect the membranes (tissue linings) of the respiratory tract, eyes, intestines, and urinary tract. Conjunctivitis is the inflammation of the clear inside lining of the eyelids and the outer layer of the sclera and is commonly referred to as “pink eye.” It can have either infectious or non-infectious causes. A common cause of infectious conjunctivitis is by the DNA virus Adenovirus which consists of several different serotypes between 65% and 90% of cases of viral conjunctivitis are caused by adenoviruses, and they produce two of the common clinical entities associated with viral conjunctivitis, pharyngoconjunctival fever and epidemic keratoconjunctivitis., whereas epidemic keratoconjunctivitis is more severe and presents with watery discharge, hyperemia, and ipsilateral lymphadenopathy. Adenovirus is highly contagious, so multiple cases are common in close-contact settings .The types of adenovirus causing pinkeye may be transmitted by water (in lakes and swimming pools), by sharing contaminated objects (such as towels or toys), or by touch. Patients should avoid touching their eyes, shaking hands, and sharing towels, among other activities. Transmission may occur through accidental inoculation of viral particles from the patient's hands or by contact with infected upper respiratory droplets, fomites, or contaminated swimming pools. Purpose: To find out the role and molecular epidemiological feature of adenovirus as etiologic agent in acute conjunctivitis in Saudi Arabia, In addition highlight the importance of implementing the proper infection control practices in ambulatory care. Methods: This was a prospective observational study conducted at outpatient clinic at one of Specialized Eye Hospital in Jeddah Kingdom of Saudi Arabia. Dates of the study were from October 2013 till April 2014. This study included 404 patients with acute follicular conjunctivitis presented to outpatient clinic. All specimens were examined by direct immunofluorescence antibody test for adenovirus. The positive specimens were then subjected for PCR genotyping. Results: Adenovirus was detected in 83 patients out of 404 (20.5%). 14 cases out of 83 (16.8%) were healthcare associated infection. The percentages of different serotypes of adenovirus were as follows; the predominant serotype was Ad4 24 out of 83 (28.9%), then Ad19 was 19 out of 83 (22.8 %), whereas Ad8, Ad37, Ad11, Ad3 and were identified in 8.4%, 4.8%, 3.6 %, and 3.6% respectively. Conclusion: This study confirmed the endemicity of adenoviruses as etiological agent of acute conjunctivitis, You can protect yourself and others from adenoviruses illnesses by Wash your hands often with soap and water &, keep surfaces clean, &strictly follow infection control practices.
机译：背景：腺病毒是一类病毒，可以感染呼吸道，眼睛，肠和尿道的膜（组织内膜）。结膜炎是眼睑透明内层和巩膜外层的炎症，通常被称为“粉红色眼”。它可能具有传染性或非传染性原因。感染性结膜炎的常见原因是DNA病毒腺病毒，它由65％到90％的病毒性结膜炎病例中的几种血清型组成，由腺病毒引起，它们产生了与病毒性结膜炎相关的两种常见临床实体，即咽结膜炎。和流行性角结膜炎，而流行性角结膜炎则更为严重，并伴有水样分泌物，充血和同侧淋巴结病。腺病毒具有高度传染性，因此在紧密接触的环境中常见多种情况。引起红眼病的腺病毒类型可能是通过水（在湖泊和游泳池中），共享被污染的物体（例如毛巾或玩具）或通过触摸传播的。 。患者应避免触摸眼睛，握手和共享毛巾等活动。可能通过意外接种患者手中的病毒颗粒或接触被感染的上呼吸道飞沫，污染物或受污染的游泳池而发生传播。目的：了解沙特阿拉伯在急性结膜炎中腺病毒作为病原体的作用和分子流行病学特征，此外，还强调了在门诊护理中实施正确的感染控制措施的重要性。方法：这是在沙特阿拉伯吉达王国的一家专门眼科医院的门诊进行的前瞻性观察研究。研究日期为2013年10月至2014年4月。该研究包括404例急性滤泡性结膜炎患者，就诊于门诊。通过直接免疫荧光抗体测试检查所有标本的腺病毒。然后对阳性样本进行PCR基因分型。结果：404例患者中有83例检出腺病毒（占20.5％）。 83例中有14例（16.8％）为医疗保健相关感染。腺病毒不同血清型的百分比如下：血清型为83的Ad4 24（28.9％），随后的Ad19为83的19（22.8％），而Ad8，Ad37，Ad11，Ad3的血清型分别为8.4％，4.8％，3.6％和3.6％分别。结论：这项研究证实了腺病毒是急性结膜炎的病原体，具有流行性。您可以通过经常用肥皂和水洗手并保持表面清洁并严格遵循感染控制措施来保护自己和他人免受腺病毒病的侵害。

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