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首页> 外文期刊>American Journal of Translational Research >The change tendency of PI3K/Akt pathway after spinal cord injury
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The change tendency of PI3K/Akt pathway after spinal cord injury

机译：脊髓损伤后PI3K / Akt途径的变化趋势

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Spinal cord injury (SCI) refers to the damage of spinal cord’s structure and function due to a variety of causes. At present, many scholars have confirmed that apoptosis is the main method of secondary injury in spinal cord injury. In view of understanding the function of PI3K/Akt pathway on spinal cord injury, this study observed the temporal variation of key molecules (PI3K, Akt, p-Akt) in the PI3K/Akt pathway after spinal cord injury by immunohistochemistry and Western-blot. The results showed that the expression of PI3K, Akt and p-Akt display a sharp increase one day after the spinal cord injury, and then it decreased gradually with the time passing by, but the absolute expression was certainly higher than the normal group. These results indicate that the PI3K/Akt signaling pathway is involved in the spinal cord injury and the mechanism may be related to apoptosis.
机译：脊髓损伤（SCI）是指由于多种原因导致的脊髓结构和功能受损。目前，许多学者已经证实凋亡是脊髓损伤继发性损伤的主要方法。为了了解PI3K / Akt通路在脊髓损伤中的功能，本研究通过免疫组织化学和Western印迹观察了脊髓损伤后PI3K / Akt通路中关键分子（PI3K，Akt，p-Akt）的时间变化。 。结果表明，脊髓损伤后一天PI3K，Akt和p-Akt的表达急剧增加，但随着时间的流逝逐渐下降，但绝对表达量肯定高于正常组。这些结果表明PI3K / Akt信号通路参与脊髓损伤，其机制可能与细胞凋亡有关。

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