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首页> 外文期刊>Current Applied Polymer Science >Comparative Influence of Two Compositional Modifications on Maximum Exotherm Temperature and Other Properties of an Antibiotic-Loaded PMMA Bone Cement | Bentham Science
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Comparative Influence of Two Compositional Modifications on Maximum Exotherm Temperature and Other Properties of an Antibiotic-Loaded PMMA Bone Cement | Bentham Science

机译：两种成分改性对抗生素载PMMA骨水泥最大放热温度及其他性能的比较影响边沁科学

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Background: Poly(methyl methacrylate) (PMMA) bone cement is widely used in cementedarthroplasties. One shortcoming of the cement is its high value of the maximum temperature reachedduring polymerization (Tmax), which, it has been postulated, plays a role in various deleterious phenomenasuch as thermal necrosis of peri-prosthetic tissues.Purpose: This was to use the results of an investigation of the influence of one modification of thecomposition of the powder (addition of a phase-change material (PCM)) of a commercially-availablegentamicin-loaded PMMA bone cement and one modification of the liquid of the cement (a chainstoppingagent (CSA)) on Tmax and 10 other clinically-relevant properties of the cement to identify experimentalcement formulation(s) that warrant(s) further evaluation as possible alternative(s) to thecontrol cement.Materials and Methods: The PCM was microencapsulated paraffin (MEPAR) (5, 15, and 25wt./wt.%) and the CSA was (1-dodecyl mercaptan (DDM) (1, 2, and 3 vol./vol.) Other cement propertiesdetermined included doughing time (tdough), setting time (tset), compressive strength (σc), radiopacity,and amount of gentamicin eluted.Results: Relative to the value for the control cement, Tmax for each experimental cement formulationwas significantly lower, but the changes in the other properties varied from significant to insignificant.An outcome of the application of a validated materials selection methodology to the collection ofproperty results led to a ranking of the experimental cement formulations.Conclusion: The formulation in which 2 or 3 vol./vol.% DDM was added to the cement liquid shouldbe evaluated further as possible alternatives to the control cement.
机译：背景：聚甲基丙烯酸甲酯（PMMA）骨水泥被广泛应用于骨水泥成形术中。水泥的一个缺点是其在聚合过程中达到的最高温度（Tmax）较高，据推测，它在各种有害现象中（例如假体周围组织的热坏死）起着一定作用。研究一种市售载有庆大霉素的PMMA骨水泥的粉末组成的一种改变（添加相变材料（PCM））和水泥液体的一种改变（一种链终止剂（CSA）的影响））在水泥的Tmax和其他10种与临床相关的特性上，以鉴定有必要进一步评估作为对照水泥的可能替代品的实验用水泥配方。材料和方法：PCM是微囊化石蜡（MEPAR） （5、15和25wt./wt.%)，CSA为（1-十二烷基硫醇（DDM）（1、2和3体积/体积））。确定的其他水泥性能包括生面团时间（tdough），凝固时间（tset），压缩结果：相对于对照水泥的值，每种实验水泥配方的Tmax均显着降低，但其他特性的变化从显着到不显着。结论：对水泥液中添加了2％或3％（体积/体积）DDM的配方应进行进一步评估。替代对照水泥。

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