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首页> 外文期刊>Anais da Academia Brasileira de Ciencias >Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acari?oba) in mice
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Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acari?oba) in mice

机译：伞形科伞形藻（Hyalcotyum umbellata L.，Araliaceae）的镇痛和抗炎活性的评估

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摘要

The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acari?oba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acari?oba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.
机译：伞形鞘藻（Hydrocotyle umbellata L.）是Araliaceae家族的一个标本，通常被称为acari？oba。它在民间医学中的适应症包括皮肤溃疡的治疗和风湿病。这项研究的目的是评估阿加里巴巴地下部分（EEA）的乙醇提取物的镇痛和抗炎活性。在乙酸诱导的扭体试验和福尔马林试验的两个阶段中，EEA均降低了动物的伤害反应。 EEA还通过增加热板测试中的疼痛潜伏期表现出了脊髓上镇痛活性。此外，EEA减少了角叉菜胶诱发的胸膜炎中白细胞向胸膜腔的迁移和血浆外渗，除了减少了由角叉菜胶诱发的水肿直至第二个小时，还减少了右旋糖酐诱发的水肿。总之，我们的结果表明，伞形花椒的EEA具有止痛和抗炎作用，并且对这些药理作用可能与活性的抑制或不同介质（如组胺和5-羟色胺）的释放减少有关。

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