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首页> 外文期刊>Anais da Academia Brasileira de Ciencias >Alcohol Effects on the P2 component of Auditory Evoked Potentials
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Alcohol Effects on the P2 component of Auditory Evoked Potentials

机译：酒精对听觉诱发电位P2成分的影响

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This is a second part of a research aimed to study the effects of alcohol on the electrophysiological processes in student volunteers. The first part showed that alcohol slowed the Omitted Stimulus Potential (OSP). This work studied the ethanol effects on the parameters (i.e. rate of rise, amplitude and peak latency) of the P2 component of the evoked potentials (EPs) yielded by trains of auditory stimuli. It is hypothesized here that if P2 and OSP waves share some common neural processes then alcohol should also affect these specific parameters. A dose of 0.8 g/kg of alcohol or a placebo (0 g/kg) was administered to two groups of 15 young men who were tested before and again after treatment. The pre-post treatment change in each of the measurements was used to assess the treatment effects. The results showed that compared to placebo, alcohol slowed the P2 rise rate and reduced its amplitude, with no effects on peak latency. The rise rate is more sensitive to alcohol but more resistant to the adaptation process. Alcohol resembles the response inhibition model acting against the adaptation. The rise rate of the P2 and the OSP waves are affected by alcohol in a similar fashion, suggesting similar neural generative mechanisms.
机译：这是旨在研究酒精对学生志愿者的电生理过程影响的研究的第二部分。第一部分显示酒精会减慢被忽略的刺激潜能（OSP）。这项工作研究了乙醇对一系列听觉刺激产生的诱发电位（EPs）的P2成分的参数（即上升速率，幅度和峰值潜伏时间）的影响。在这里假设如果P2和OSP波共享一些共同的神经过程，那么酒精也会影响这些特定参数。在两组治疗前和治疗后的15位年轻男性中，分别服用0.8 g / kg酒精或安慰剂（0 g / kg）。每个测量值的治疗后变化均用于评估治疗效果。结果表明，与安慰剂相比，酒精可降低P2的上升速度并降低其幅度，而对峰值潜伏期没有影响。上升速率对酒精更敏感，但对适应过程更具抵抗力。酒精类似于针对这种适应的反应抑制模型。 P2和OSP波的上升速率受酒精影响的方式相似，表明存在类似的神经生成机制。

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