• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ageing Research >IGF-1: a marker of individual life-span in a primate
【24h】

IGF-1: a marker of individual life-span in a primate

机译：IGF-1：灵长类动物个体寿命的标志

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The development of biological markers to evaluate individual life-span is badly needed because of the high cost and time duration that are necessary to assess the ageing process in long-living organisms such as primates. In this study, we measured insulin-like growth factor-1 (IGF-1) levels in a small, relatively short-living (maximal longevity: 12 years) primate from Madagascar, the gray mouse lemur (Microcebus murinus), in order to determine if they can be related to the rate of survival of this seasonal species. Cross-sectional blood samplings on 112 males of various ages indicated that IGF-1 levels remain high and constant during the long-day breeding seasons while a significant age-related decrease occurs from the fourth short-day resting season onward. Interestingly, in four-year-old lemurs, short-day IGF-1 body mass ratio values appeared as a good predictor of their life-span.
机译：由于评估长寿命生物（例如灵长类动物）衰老过程所必需的高成本和持续时间，迫切需要开发用于评估个体寿命的生物标记。在本研究中，我们测量了来自马达加斯加的灰色小狐猴（Microcebus murinus）的灵长类灵长类动物的小型，相对短寿（最大寿命：12年）中的胰岛素样生长因子-1（IGF-1）水平，确定它们是否与该季节性物种的存活率有关。对112名不同年龄男性的横断面血液采样表明，在漫长的繁殖季节中，IGF-1水平保持较高且恒定，而从第四个短日休息季节开始，与年龄相关的显着下降。有趣的是，在四岁的狐猴中，短日IGF-1体重比值似乎可以很好地预测它们的寿命。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号