Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata

Mondem Vasundhara; Manoj Baranwal; Nallapeta Sivaramaiah; Anil Kumar

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Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata

机译：南方红豆杉产产产生三氢尿嘧啶的内生真菌的分离与鉴定

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An endophytic fungus (strain T1) isolated from Taxus baccata was studied for the production of metabolites with anticancer and antioxidant activities. This fungus was identified as Diaporthe sp. based on rDNA-internal transcribed spacer (ITS) sequence analysis. The crude extract showed cytotoxic activity against MCF-7 and HeLa cancer cell lines, with IC50 (concentration inhibiting 50% of growth rate) values of 1058?±?44 and 1257?±?80?μg?ml?1, respectively. The scavenging activity of fungal extract increased significantly with increasing concentration [IC50 (concentration required to scavenge 50% of free radicals) 482?±?9?μg?ml?1]. Ultra-high-performance liquid chromatography-quadrupole-time of flight analysis revealed the presence of three trichalasins (trichalasin E, F and H) in the crude extract of T1 which are known to have antitumour and antioxidant activities. These results suggest that Diaporthe sp. has the potential to be used for therapeutic purposes because of its antiproliferative and antioxidant potential and also for the production of cytochalasins.

机译：研究了从红豆杉中分离出的内生真菌（菌株T1）用于生产具有抗癌和抗氧化活性的代谢产物。该真菌被鉴定为Diaporthe sp.。基于rDNA内部转录间隔区（ITS）序列分析。粗提物显示出对MCF-7和HeLa癌细胞系的细胞毒性活性，IC50（浓度抑制50％的生长速率）的IC50值分别为1058？±？44和1257？±？80？μg？ml？1。真菌提取物的清除活性随浓度的增加而显着增加[IC50（清除50％自由基所需的浓度）482？±？9？μg？ml？1]。超高效液相色谱-四极杆飞行时间分析显示，T1粗提物中存在三种Trichalasins（trichalasin E，F和H），已知它们具有抗肿瘤和抗氧化活性。这些结果表明Diaporthe sp。由于其具有抗增殖和抗氧化的潜力，还具有用于细胞松弛素生产的潜力。

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《Annals of microbiology》 |2017年第3期|共7页
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Mondem Vasundhara; Manoj Baranwal; Nallapeta Sivaramaiah; Anil Kumar;
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Isolation and characterization of trichalasin-producing endophytic fungus from Taxus baccata

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