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首页> 外文期刊>Annals of Maxillofacial Surgery >Healer granules in nonhealing infected wounds
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Healer granules in nonhealing infected wounds

机译：伤口未愈合的愈合剂颗粒

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Background: Head-and-neck infection is one of the most frequently encountered issues in the field of oral and maxillofacial surgery. Most of the cases with head-and-neck infections are managed by empirical antibiotic therapy and extraction of offending infected tooth/teeth. However, long-term systemic antibiotic therapy can have profound compromising effects on host immune defense and thereby hamper healing, which, in turn, may lead to life-threatening complications such as localized septic foci or widespread septicemia at times leading to death of an individual. In this study, we are reviewing management of 15 cases with space infection in the maxillofacial region by local drug delivery with the help of collagen particles combined with mupirocin 2% w/w and metronidazole 1% w/w (BioFil-AB). We intend to study its efficacy in managing the space infections associated with extraoral infected wound as well as in preventing hazards of long-term systemic antibiotic therapy. Aims: The aim of this study is to assess the efficacy of the topical use of BioFil-AB in infected maxillofacial wounds. Materials and Methods: A total of 15 patients with infected maxillofacial wounds reporting to the department of oral and maxillofacial surgery were categorized into three groups depending on the severity of infections. Of these 15 cases, 8 patients were suffering from infected extraoral wounds, 3 had traumatic infection, and remaining 4 had extraoral consolidated abscesses due to odontogenic infection. All patients had a history of prior antibiotic therapy. Incision and drainage of the septic focus/foci were performed in most of the cases, and healing of the site was assessed after application of topical BioFil-AB (mupirocin + metronidazole + collagen granules) dressing. Results and Conclusion: Dressing with BioFil-AB granules proved to be efficient in control of infection as well as in promoting uneventful wound healing, especially with good follow-up. Further studies with a large sample size may be necessary to corroborate the findings and provide substantial evidence. This novel local drug delivery therapy will definitely help in maintenance of good host immune response as well as in preventing or minimizing occurrence of antibiotic resistance.
机译：背景：头颈部感染是口腔颌面外科领域最常见的问题之一。大多数头颈部感染病例都通过经验性抗生素治疗和拔出令人讨厌的感染牙齿/牙齿来治疗。但是，长期的全身性抗生素治疗可能会对宿主的免疫防御系统产生深远的损害，从而阻碍其愈合，进而可能导致危及生命的并发症，例如局部化脓性病灶或广泛的败血病，有时甚至导致个体死亡。 。在这项研究中，我们正在对15例上颌面部空间感染的病例进行管理，这些病例是通过胶原蛋白与莫匹罗星2％w / w和甲硝唑1％w / w（BioFil-AB）结合的胶原蛋白颗粒的局部给药来进行的。我们打算研究其在处理与口腔外感染伤口相关的空间感染以及预防长期全身抗生素治疗的危害方面的功效。目的：本研究的目的是评估在感染的颌面部伤口中局部使用BioFil-AB的功效。材料和方法：根据感染的严重程度，将总共15例上颌面部伤口感染的患者报告给口腔颌面外科，将其分为三类。在这15例病例中，有8例患有口腔外伤口感染，其中3例患有外伤性感染，其余4例由于牙源性感染而存在口腔外合并脓肿。所有患者均曾接受过抗生素治疗史。在大多数情况下，会进行脓疱病灶/灶的切开引流，并在应用局部BioFil-AB（莫匹罗星+甲硝唑+胶原颗粒）敷料后评估该部位的愈合情况。结果与结论：BioFil-AB颗粒敷料被证明可有效控制感染并促进伤口愈合良好，尤其是随访良好。为了证实研究结果并提供大量证据，可能需要进行大样本量的进一步研究。这种新颖的局部药物递送疗法必将有助于维持良好的宿主免疫反应，以及预防或最大程度降低抗生素耐药性。

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