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首页> 外文期刊>Annals of microbiology >Culturable bioactive actinomycetes from the Great Indian Thar Desert
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Culturable bioactive actinomycetes from the Great Indian Thar Desert

机译：来自大印度塔尔沙漠的可培养生物活性放线菌

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The present study was attempted to determine the antimicrobial potential of actinomycetes from the Great Indian Thar Desert. A total of 100 different morphotypes based on phenotypic characterization were isolated from desert ecosystems located in the northwest of India and tested for their antimicrobial activity by the cross-streak method. Among the strains tested, 13 actinomycetes exhibiting strong antimicrobial activities against several test organisms, including multidrug resistant bacteria (MRSA) were chosen for a phylogenetic diversity study. The results of 16S rRNA gene sequencing showed their affiliation to actinobacterial genera: Actinomadura, Nocardia, Nonomuraea, Spirillispora, and Streptomyces. Three of these isolates were considered to be new members of the Streptomyces genus and another strain also seemed to be a new species of the genus Spirillispora. Among these strains, five were chosen to study the bioactive products using Q-Tof-MS because of their broad spectrum activity against the panel of test pathogens used. The results showed that they produce many known compounds and might produce few unknown compounds as well. This is the first such report on the selective isolation of actinomycetes from the Great Indian Thar desert, and their screening for antibacterial potential. This ecosystem has never before been explored to this extent.
机译：本研究试图确定来自大印度塔尔沙漠的放线菌的抗菌潜力。从表型特征出发，从印度西北部的沙漠生态系统中分离出总共100种不同的形态型，并通过交叉条纹法测试了它们的抗菌活性。在测试的菌株中，选择13种放线菌对多种测试生物（包括耐多药细菌（MRSA））表现出强大的抗菌活性，以进行系统发育多样性研究。 16S rRNA基因测序的结果表明它们与放线菌属有关联：放线菌属，诺卡氏菌，野野菌属，螺旋藻和链霉菌。这些分离物中的三个被认为是链霉菌属的新成员，另一个菌株似乎也是螺旋藻属的新种。在这些菌株中，选择了五种来研究使用Q-Tof-MS的生物活性产物，因为它们对使用的测试病原体具有广谱活性。结果表明，它们产生许多已知化合物，并且可能也产生很少的未知化合物。这是关于从大印度塔尔沙漠中选择性分离放线菌及其筛选抗菌潜力的首份此类报道。这种生态系统从来没有被探索到这种程度。

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